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Asymmetric Cell Division

  • Alvaro Macieira-Coelho

Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 45)

Table of contents

About this book

Introduction

Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.

Keywords

Biology of Cancers Cell Differentiation DNA Development Hydra Immune System Stem Cells aging cell division

Editors and affiliations

  • Alvaro Macieira-Coelho
    • 1
  1. 1.INSERMVersaillesFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-69161-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-69160-0
  • Online ISBN 978-3-540-69161-7
  • Series Print ISSN 0079-6484
  • Buy this book on publisher's site