Advertisement

Liver Radioembolization with 90Y Microspheres

  • José I. Bilbao
  • Maximilian F. Reiser

Part of the Medical Radiology book series (MEDRAD)

Table of contents

  1. Front Matter
    Pages I-XII
  2. Andrew S. Kennedy, William A. Dezarn, Patrick McNeillie
    Pages 1-9
  3. Ralf-Thorsten Hoffmann, Tobias F. Jakobs, Maximilian F. Reiser
    Pages 11-14
  4. Christoph J. Zech, Maximilian F. Reiser
    Pages 15-28
  5. Antonio Martínez de la Cuesta, Alberto Alonso-Burgos, Isabel Vivas, Riad Salem, Jose I Bilbao
    Pages 29-42
  6. Riad Salem, Robert J. Lewandowski, Robert K. Ryu, Kent Sato, Antonio Martinez de la Cuesta
    Pages 43-50
  7. Andrew S. Kennedy, William A. Dezarn, Patrick McNeillie
    Pages 51-59
  8. José F. Boán, Marta Valero, Javier Arbizu
    Pages 61-73
  9. Mercedes Iñarrairaegui, Bruno Sangro
    Pages 107-115
  10. Andrew S. Kennedy, William A. Dezarn, Patrick McNeillie
    Pages 117-124
  11. Javier Rodriguez, Ana Chopitea, Antonio Viudez, Jesús Garcia-Foncillas
    Pages 125-134
  12. Douglas M. Coldwell, Andrew S. Kennedy, Charles Nutting
    Pages 135-137
  13. Ralf-Thorsten Hoffman, José I. Bilbao, Tobias F. Jakobs, Lourdes Diaz-Dorronsoro, Laurent Desloques, Maximilian F. Reiser
    Pages 139-146
  14. Riad Salem, Saad Ibrahim, Bassel Atassi, Robert J. Lewandowski
    Pages 147-156
  15. Back Matter
    Pages 157-163

About this book

Introduction

This book provides an in-depth account of all aspects of radioembolization, a relatively novel technique based on the efficacy of radiotherapy for the treatment of liver tumors. In the past, the therapeutic radiation dose needed to treat a tumoral area has been sufficiently high to produce permanent damage to the nontumoral liver parenchyma. Radioembolization attempts to overcome this problem by combining embolization (intravascular deployment of particles) and brachytherapy (local administration of radiotherapy with the aid of a device, namely the particles themselves). The technique is based on improvements in percutaneous endovascular procedures which have allowed the deployment of small (25-35 µm) microspheres loaded with yttrium-90 that deliver high doses of beta-radiation specifically to the tumoral area. Performance of the procedure demands close familiarity with the hepatic vascular anatomy in order to ensure avoidance of vessels going to other territories. Furthermore, detailed knowledge of liver function, tumor volume, and liver vascular shunting is needed in order to calculate the appropriate therapeutic dose in each particular case. All of these topics are addressed in depth in this book, and initial clinical results are presented, showing that constant local control can be achieved with a reasonably low rate of complications. These promising results may lead to a progressive change in the therapeutic indication for radioembolization, and in some cases it could even become the therapy of choice.

Keywords

Tumor brachytherapy carcinoma embolization hepatocarcinoma liver metastases liver tumor neuroendocrine tumor radioembolization

Editors and affiliations

  • José I. Bilbao
    • 1
  • Maximilian F. Reiser
    • 2
  1. 1.Department of Radiology Clínica UniversitariaUniversidad de NavarraPamplonaSpain
  2. 2.Department of Clinical RadiologyUniversity Hospitals - Grosshadern and Innenstadt Ludwig-Maximilians-University of MunichMunichGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-35423-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-35421-5
  • Online ISBN 978-3-540-35423-9
  • Series Print ISSN 0942-5373
  • Buy this book on publisher's site