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Analysis of Pharmaceuticals by Capillary Electrophoresis

  • Kevin D. Altria

Part of the Chromatographia CE Series book series (CHROM, volume 2)

Table of contents

  1. Front Matter
    Pages I-XII
  2. Kevin D. Altria
    Pages 21-43
  3. Kevin D. Altria
    Pages 44-69
  4. Kevin D. Altria
    Pages 70-100
  5. Kevin D. Altria
    Pages 121-132
  6. Kevin D. Altria
    Pages 153-161
  7. Kevin D. Altria
    Pages 193-205
  8. Kevin D. Altria
    Pages 206-222
  9. Kevin D. Altria
    Pages 251-262
  10. Kevin D. Altria
    Pages 263-268
  11. Back Matter
    Pages 280-285

About this book

Introduction

During the 1980's the analysis of pharmaceuticals was dominated by the use of High Perfor­ mance Liquid Chromatography (HPLC). Other separative techniques such as Gas Chromato­ graphy and Thin Layer Chromatography offered alternatives but their quantitative capabili­ ties and/or solute range could not approach that of HPLC. The majority of pharmaceuticals are ionic and it would be reasonable to assume that electrophoresis may be useful in the analysis of pharmaceuticals. However, the electrophore­ tic instruments available in the 1980's were labour intensive and employed post-separation detection procedures. During the late 1980's and early 1990's extensive research was con­ ducted into the possibilities of conducting electrophoretic separations in capillaries. This approach allowed on-line detection and could be performed on fully automated equipment. This research led to the advent of modern day capillary electrophoresis (CE) instruments which offer similar performance and automation levels to that of HPLC. Research was also focused on developing applications for CE and particular attention was paid to applications within the pharmaceutical analysis area. These applications proved that CE could be applied to a wide range of drug types including water insoluble and neutral compounds. The ability to achieve efficient chiral separations of drugs also increased the popularity of the technique. CE with indirect UV detection has become established as a simple and effective alternative to ion-exchange chromatography for the determination of small inorganic or organic ions.

Keywords

Arbeit Elektrophorese Praxis Vitamin A chromatography design drugs material optimization pharmaceutical

Authors and affiliations

  • Kevin D. Altria
    • 1
  1. 1.Pharmaceutical DevelopmentGlaxo Wellcome R&DWare, Herts.UK

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-322-85011-9
  • Copyright Information Vieweg+Teubner Verlag | Springer Fachmedien Wiesbaden GmbH, Wiesbaden 1998
  • Publisher Name Vieweg+Teubner Verlag
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-322-85013-3
  • Online ISBN 978-3-322-85011-9
  • Series Print ISSN 1615-2255
  • Buy this book on publisher's site