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Stem Cell Genetics for Biomedical Research

Past, Present, and Future

  • Book
  • © 2018

Overview

  • This volume presents an up-to-date compendium of major scientific breakthroughs on human diseases, drug screenings, personalized medicine and regenerative approaches by using stem cells to model or treat the disorders
  • This book covers what would be the desired strategy for the years to come, by methodically dissecting limitations in our current methodology and understanding of stem cells technology
  • This book also summarizes state-of-the-art technology (genomics and epigenomics, crispr/cas9, epigenetic tools, bioinformatics approaches, etc) that will push further the applicability and validity of the stem cell application in biomedical research

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About this book

This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. 

In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.



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Keywords

Table of contents (15 chapters)

  1. Stem Cells for Brain Disorders

  2. Stem Cells for Cardiovascular Diseases

  3. Stem Cells for General Medicine

  4. Technical Challenges and Future

Editors and Affiliations

  • Duran i Reynals Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

    Raul Delgado-Morales

About the editor

Raul Delgado-Morales holds a PhD in Neuroscience. He completed his doctoral studies at the Universitat Autònoma de Barcelona working in the field of epigenetics as it relates to depression. After that he received a Marie Curie Postdoctoral Fellowship, to continue his research as a postdoc at the Max Planck Institute of Psychiatry in Munich. There he focused on Alzheimer’s disease. After four years in Germany, he moved to Bellvitge Biomedical Research Institute (IDIBELL), in Barcelona, to lead research on neuroepigenomics. Currently he is the Scientific Deputy Director of IDIBELL.

Bibliographic Information

  • Book Title: Stem Cell Genetics for Biomedical Research

  • Book Subtitle: Past, Present, and Future

  • Editors: Raul Delgado-Morales

  • DOI: https://doi.org/10.1007/978-3-319-90695-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-90694-2Published: 09 July 2018

  • Softcover ISBN: 978-3-030-08076-1Published: 14 December 2018

  • eBook ISBN: 978-3-319-90695-9Published: 27 June 2018

  • Edition Number: 1

  • Number of Pages: XI, 426

  • Number of Illustrations: 32 illustrations in colour

  • Topics: Stem Cells, Human Genetics, Molecular Medicine

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