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Molecular Mechanisms of Notch Signaling

  • Book
  • © 2018


  • Provides the most recent overview of Notch signal transduction
  • Is an in-depth introduction into molecular mechanisms of signal transduction exemplified by the Notch signaling pathway
  • Covers topics such as Notch signaling in combination with senescence, blood vessel formation, leukemogenesis, neurogenesis and stem cell functions

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1066)

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About this book

This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression.

Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated.

This book is not only intended for experts but it should also be a usefulresource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.

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Table of contents (18 chapters)

  1. Introduction

  2. Molecular Mechanisms of Receptor/Ligand Interactions

  3. Intracellular Signaling Mechanisms

  4. Disease Links and Therapeutics

Editors and Affiliations

  • Institute of Biochemistry, University of Giessen, Giessen, Germany

    Tilman Borggrefe, Benedetto Daniele Giaimo

Bibliographic Information

  • Book Title: Molecular Mechanisms of Notch Signaling

  • Editors: Tilman Borggrefe, Benedetto Daniele Giaimo

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-89511-6Published: 03 August 2018

  • Softcover ISBN: 978-3-030-07789-1Published: 14 December 2018

  • eBook ISBN: 978-3-319-89512-3Published: 20 July 2018

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXVII, 398

  • Number of Illustrations: 3 b/w illustrations, 56 illustrations in colour

  • Topics: Receptors, Protein-Ligand Interactions, Protein Structure

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