Damage-Associated Molecular Patterns in Human Diseases

Volume 1: Injury-Induced Innate Immune Responses

  • Walter Gottlieb Land

Table of contents

  1. Front Matter
    Pages i-xlviii
  2. The Three Major Paradigms in Modern Immunology

    1. Front Matter
      Pages 1-1
    2. Walter Gottlieb Land
      Pages 13-27
  3. The Innate Immune System: an Organ of Perception Determined to Maintain Homeostasis

    1. Front Matter
      Pages 31-31
    2. Walter Gottlieb Land
      Pages 33-42
    3. Walter Gottlieb Land
      Pages 43-108
  4. The Whole Family of Mammalian Innate Immune Cells

    1. Front Matter
      Pages 111-111
    2. Walter Gottlieb Land
      Pages 113-113
    3. Walter Gottlieb Land
      Pages 115-158
    4. Walter Gottlieb Land
      Pages 159-186
  5. The World of DAMPs

  6. Cellular Stress Responses and Regulated Cell Death

    1. Front Matter
      Pages 371-371
    2. Walter Gottlieb Land
      Pages 377-426
    3. Walter Gottlieb Land
      Pages 427-466
  7. Innate Immune Effector Responses

    1. Front Matter
      Pages 471-471
    2. Walter Gottlieb Land
      Pages 475-590
    3. Walter Gottlieb Land
      Pages 591-634
    4. Walter Gottlieb Land
      Pages 635-658
  8. Function of Innate Lymphoid Cells and Unconventional T Cells with Partial Innate Function

    1. Front Matter
      Pages 661-661
    2. Walter Gottlieb Land
      Pages 665-691
    3. Walter Gottlieb Land
      Pages 693-711
  9. DAMPs Promoting Adaptive Immunity and Tissue Repair

About this book


This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.



innate immunity damage-associated molecular patterns autoimmune diseases metabolic diseases traumatic diseases allergic diseases cardiovascular diseases neurodegenerative diseases malignant diseases cellular stress responses

Authors and affiliations

  1. 1.University of StrasbourgMolecular ImmunoRheumatology, Laboratory of Excellence TransplantexStrasbourgFrance

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-78654-4
  • Online ISBN 978-3-319-78655-1
  • Buy this book on publisher's site