Advertisement

Sesquiterpene Lactones

Advances in their Chemistry and Biological Aspects

  • Valeria Patricia Sülsen
  • Virginia Susana Martino

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Chemical and Biochemical Aspects of Sesquiterpene Lactones

    1. Front Matter
      Pages 1-1
    2. Valeria P. Sülsen, Virginia S. Martino
      Pages 3-17
    3. Mateus Feitosa Alves, Luciana Scotti, Fernando Batista Da Costa, Marcus Tullius Scotti
      Pages 31-45
    4. María Perassolo, Alejandra Beatriz Cardillo, Víctor Daniel Busto, Ana María Giulietti, Julián Rodríguez Talou
      Pages 47-91
    5. Francis J. Barrios
      Pages 93-117
    6. Valeria P. Sülsen, Cesar A. N. Catalán, Virginia S. Martino
      Pages 119-136
    7. Valeria P. Sülsen, Osvaldo J. Donadel, Cesar A. N. Catalán
      Pages 137-172
  3. Biological Activities of Sesquiterpene Lactones

    1. Front Matter
      Pages 173-173
    2. Andrés Sánchez Alberti, Natacha Cerny, Augusto Bivona, Silvia I. Cazorla
      Pages 175-196
    3. Nubia Boechat, Luiz Carlos da Silva Pinheiro, Flavia Fernandes da Silveira
      Pages 197-221
    4. María E. Lombardo, Alcira Batlle
      Pages 223-240
    5. Esteban Lozano, Renata Spina, Patricia Barrera, Carlos Tonn, Miguel A. Sosa
      Pages 241-273
    6. María Victoria Castelli, Silvia Noelí López
      Pages 275-301
    7. Claudia A. Anesini, María Rosario Alonso, Renzo F. Martino
      Pages 303-323
    8. María Rosario Alonso, Claudia A. Anesini, Renzo F. Martino
      Pages 325-346
  4. Sesquiterpene Lactones: Medicinal Chemistry Approach

    1. Front Matter
      Pages 347-347

About this book

Introduction

This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed.

The book begins by describing the chemical characteristics of STLs, their classification in different skeleton types, synthesis, distribution in nature and their most important biological properties. An overview of the group's main representatives, based on their importance for human health, as well as an update of the most recently isolated STLs, follow. The authors also provide an overview of the most common methods described in the literature for the extraction, purification, identification and structure elucidation of STLs, while also highlighting more recently developed methods.

Furthermore, experts in the field provide an in-depth discussion of the most commonly employed in vitro and in vivo antiprotozoal assays against the different stages of parasites, as well as STLs' properties as anticancer agents in numerous cancer cell lines and animal models. Lastly, the book presents examples of the in vitro and in vivo activity of STLs and their mechanism of antiprotozoal action, together with an analysis of ultrastructural alterations, observed using TEM techniques.

The book is aimed at scientists working on natural products: both those investigating this particular group of compounds and those who wish to further explore its potential as new drugs for medical conditions such as protozoal diseases and cancer.

Keywords

chemistry of sesquiterpene lactones pharmacology of sesquiterpene lactones antiprotozoal activity of sesquiterpene lactones antiproliferative activity of sesquiterpene lactones SAR studies of sesquiterpene lactones synthesis of sesquiterpene lactones sesquiterpene lactones synthetic derivatives isolation of sesquiterpene lactones characterization of sesquiterpene lactones

Editors and affiliations

  • Valeria Patricia Sülsen
    • 1
  • Virginia Susana Martino
    • 2
  1. 1.University of Buenos AiresCONICET University of Buenos Aires, Autonomous City of Buenos AiresBuenos AiresArgentina
  2. 2.University of Buenos AiresCONICET University of Buenos Aires, Autonomous City of Buenos AiresBuenos AiresArgentina

Bibliographic information