Acute Neuronal Injury

The Role of Excitotoxic Programmed Cell Death Mechanisms

  • Denson G. Fujikawa

Table of contents

  1. Front Matter
    Pages i-xii
  2. General Considerations

    1. Front Matter
      Pages 1-1
    2. Yubin Wang, Xiaoning Bi, Michel Baudry
      Pages 19-35
  3. Traumatic Brain Injury

    1. Front Matter
      Pages 37-37
    2. W. Brad Hubbard, Laurie M. Davis, Patrick G. Sullivan
      Pages 63-81
  4. Focal Cerebral Ischemia

    1. Front Matter
      Pages 101-101
  5. Transient Global Cerebral Ischemia

    1. Front Matter
      Pages 115-115
    2. Yang Sun, Tuo Yang, Jessica Zhang, Armando P. Signore, Guodong Cao, Jun Chen et al.
      Pages 117-132
    3. Marta M. Vieira, Ana Luísa Carvalho
      Pages 133-151
    4. M. Jake Pushie, Vedashree R. Meher, Nicole J. Sylvain, Huishu Hou, Annalise T. Kudryk, Michael E. Kelly et al.
      Pages 153-171
  6. Hypoglycemic Neuronal Injury

    1. Front Matter
      Pages 173-173
    2. Roland N. Auer
      Pages 175-188
  7. Seizure-Induced Neuronal Death

  8. Back Matter
    Pages 213-215

About this book


An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. 

The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.


DNA Flow Nervous System Neurology Neuroscience apoptosis caspase-independent mechanisms excitotoxicity necrosis neurons programmed cell death

Editors and affiliations

  • Denson G. Fujikawa
    • 1
  1. 1.Department of NeurologyVA Greater Los Angeles Healthcare SystemNorth HillsUSA

Bibliographic information