Multifunctional Gold Nanostars for Cancer Theranostics

  • Yang Liu

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Yang Liu
    Pages 1-14
  3. Yang Liu
    Pages 39-43
  4. Yang Liu
    Pages 65-67
  5. Back Matter
    Pages 69-71

About this book

Introduction

This thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model.

Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer.

The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.

Keywords

Multifunctional Nanoprobe Gold Nanostars (GNS) Nanomedicine Cancer Theranostics Cancer Imaging Cancer Immunotherapy Nanophotonics Surface Enhanced Raman spectroscopy (SERS) Photothermal Therapy (PTT) Two-photon photoluminescence (TPL) X-­ray computer tomography (CT) Magnetic resonance imaging (MRI) Positron emission tomography (PET) Gold Nanostars biocompability

Authors and affiliations

  • Yang Liu
    • 1
  1. 1.Department of ChemistryDuke UniversityDurhamUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-74920-4
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-74919-8
  • Online ISBN 978-3-319-74920-4
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • About this book