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Drug Resistance in Leishmania Parasites

Consequences, Molecular Mechanisms and Possible Treatments

  • Alicia Ponte-Sucre
  • Maritza Padrón-Nieves

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Emilia Díaz, Alicia Ponte-Sucre
    Pages 1-16
  3. Determinant Features in Leishmaniasis

    1. Front Matter
      Pages 17-17
    2. Gabriele Schönian, Julius Lukeš, Olivia Stark, James A. Cotton
      Pages 19-57
    3. Lenea Campino, Carla Maia
      Pages 59-83
    4. Lukasz Kedzierski, Krystal J. Evans
      Pages 109-142
  4. Challenges in the Diagnosis, Treatment and Control of Leishmaniasis in Times of Drug Resistance

    1. Front Matter
      Pages 143-143
    2. Margriet den Boer, Jorge Alvar
      Pages 145-158
    3. Shyam Sundar, Jaya Chakravarty
      Pages 159-176
    4. Olga Zerpa, Maritza Padrón-Nieves, Alicia Ponte-Sucre
      Pages 177-191
    5. Sarah Hendrickx, Louis Maes, Simon L. Croft, Guy Caljon
      Pages 193-206
  5. Molecular Features of Drug Resistant Leishmania

    1. Front Matter
      Pages 207-207
    2. Leonardo Saboia-Vahia, Jose Batista de Jesus, Patricia Cuervo
      Pages 209-245
    3. Adriano C. Coelho, Paulo C. Cotrim
      Pages 247-272
  6. Tools and Strategies to Circumvent Drug Resistance in Leishmania

    1. Front Matter
      Pages 295-295
    2. Shishir K. Gupta, Thomas Dandekar
      Pages 297-317
    3. Manu Vanaerschot, Franck Dumetz, Marlene Jara, Jean-Claude Dujardin, Alicia Ponte-Sucre
      Pages 341-366
  7. Back Matter
    Pages 367-376

About this book

Introduction

Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on the pathology of the disease, as well as on the concept of parasitic drug resistance, its molecular basis, consequences and possible treatments. A valuable resource for scientists both from academia and industry involved in biomedical research and drug design, the book provides the knowledge needed to understand leishmaniasis and to contibute to combatting this disease worldwide.

Keywords

ABC Transporters Drug Resistance Infectious Disease Leishmaniasis Parasite Vaccine Development

Editors and affiliations

  • Alicia Ponte-Sucre
    • 1
  • Maritza Padrón-Nieves
    • 2
  1. 1.Institute of Experimental MedicineUniversidad Central de VenezuelaCaracasVenezuela
  2. 2.Escuela Luis Razetti Fac de MedicineUniversidad Central de VenezuelaCaracasVenezuela

Bibliographic information