Mitochondrial Biology and Experimental Therapeutics

  • Paulo J. Oliveira

Table of contents

  1. Front Matter
    Pages i-ix
  2. Mitochondrial Biology

    1. Front Matter
      Pages 1-1
    2. Paulo J. Oliveira
      Pages 3-9
    3. Mauro Degli Esposti
      Pages 11-17
    4. Jose Viña, Consuelo Borras
      Pages 33-45
    5. Claudia Morganti, Massimo Bonora, Luigi Sbano, Giampaolo Morciano, Giorgio Aquila, Gianluca Campo et al.
      Pages 47-73
    6. Dawei Liu, Jean-Luc Perfettini, Catherine Brenner
      Pages 75-90
    7. Ignazio Grattagliano, Ornella de Bari, Domenica Di Palo, Fabrizio Montecucco, Federico Carbone, Paulo J. Oliveira et al.
      Pages 91-126
    8. Henrique Alexandrino, Anabela Rolo, José Guilherme Tralhão, Francisco Castro e Sousa, Carlos Palmeira
      Pages 127-152
    9. Kenneth J. Dornfeld, Andrew J. Skildum
      Pages 153-191
    10. Kenneth E. McMartin
      Pages 193-211
    11. Edward J. Lesnefsky, Qun Chen, Bernard Tandler, Charles L. Hoppel
      Pages 241-267
    12. Julie Massart, Annie Borgne-Sanchez, Bernard Fromenty
      Pages 269-295
  3. Mitochondrial Experimental Therapeutics: From the Bench to Industry and Patient

    1. Front Matter
      Pages 317-317
    2. Ricardo Amorim, Sofia Benfeito, José Teixeira, Fernando Cagide, Paulo J. Oliveira, Fernanda Borges
      Pages 333-358
    3. Mariusz R. Wieckowski, Alberto Danese, Giampaolo Morciano, Maciej Pronicki, Jerzy Duszynski, Paolo Pinton et al.
      Pages 359-378

About this book

Introduction

This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

Keywords

mitochondria mitochondrial therapeutics drug delivery mitochondrial disruption diseases mitochondrial-targeted agents therapeutics

Editors and affiliations

  • Paulo J. Oliveira
    • 1
  1. 1.CNC - Center for Neuroscience and Cell BiologyUniversity of CoimbraCoimbraPortugal

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-73344-9
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-73343-2
  • Online ISBN 978-3-319-73344-9
  • About this book