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Amorphous Drugs

Benefits and Challenges

  • Marzena Rams-Baron
  • Renata Jachowicz
  • Elena Boldyreva
  • Deliang Zhou
  • Witold Jamroz
  • Marian Paluch

Table of contents

  1. Front Matter
    Pages i-ix
  2. Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz, Marian Paluch
    Pages 1-7
  3. Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz, Marian Paluch
    Pages 9-39
  4. Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz, Marian Paluch
    Pages 41-68
  5. Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz, Marian Paluch
    Pages 69-106
  6. Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz, Marian Paluch
    Pages 107-157
  7. Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz, Marian Paluch
    Pages 159-223
  8. Back Matter
    Pages 225-230

About this book

Introduction

This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body. 

Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products.

 

Keywords

Glass transition Solubility enhancement Recrystallization Increasing bioavailability of drug compounds Amorphous pharmaceuticals Pharmaceutical amorphous solid dispersions Amorphous drug formulations Order and disorder in the solid state Drug solubility Absorption enhancement

Authors and affiliations

  • Marzena Rams-Baron
    • 1
  • Renata Jachowicz
    • 2
  • Elena Boldyreva
    • 3
  • Deliang Zhou
    • 4
  • Witold Jamroz
    • 5
  • Marian Paluch
    • 6
  1. 1.Institute of PhysicsUniversity of SilesiaChorzówPoland
  2. 2.Chair of Pharmaceutical Technology and BiopharmaceuticsFaculty of Pharmacy Jagiellonian University - Medical CollegeKrakówPoland
  3. 3.Institute of Solid State Chemistry and MechanochemistrySiberian Branch of the Russian Academy of SciencesNovosibirskRussia
  4. 4.AbbVieNorth ChicagoUSA
  5. 5.Chair of Pharmaceutical Technology and BiopharmaceuticsFaculty of Pharmacy Jagiellonian University - Medical CollegeKrakówPoland
  6. 6.Institute of PhysicsUniversity of SilesiaChorzówPoland

Bibliographic information