Methods and Biostatistics in Oncology

Understanding Clinical Research as an Applied Tool

  • Raphael. L.C Araújo
  • Rachel P. Riechelmann

Table of contents

  1. Front Matter
    Pages i-xii
  2. Vinicius de Lima Vazquez, Raphael L. C. Araújo
    Pages 1-8
  3. Beatriz Teixeira Costa, Isadora Santos Ferreira, Felipe Fregni
    Pages 9-22
  4. Gregory R. Pond, Samantha-Jo Caetano
    Pages 23-35
  5. Bruno S. Paolino, Raphael L. C. Araújo, David Bristol
    Pages 37-49
  6. Rachel P. Riechelmann, Raphael L. C. Araújo, Benjamin Haaland
    Pages 51-69
  7. Raphael L. C. Araújo, Rachel P. Riechelmann
    Pages 71-92
  8. Benjamin Haaland, Mina Georgieva
    Pages 93-124
  9. André Lopes Carvalho, Fabiana de Lima Vazquez, Cleyton Zanardo de Oliveira
    Pages 125-146
  10. Katherine S. Panageas, Debra A. Goldman, T. Peter Kingham
    Pages 147-164
  11. Louise Carter, Ciara O’Brien, Emma Dean, Natalie Cook
    Pages 165-187
  12. Rachel P. Riechelmann, Raphael L. C. Araújo, Axel Hinke
    Pages 189-202
  13. Deise Uema, Cheng Tzu Yen, Axel Hinke, Gilberto de Castro Jr.
    Pages 217-225
  14. Francisco Emilio Vera-Badillo, Rachel P. Riechelmann
    Pages 227-240
  15. Rodrigo Santa C. Guindalini, Rachel P. Riechelmann, Roberto Jun Arai
    Pages 241-256
  16. Pedro Aguiar Jr., Carmelia Maria Noia Barreto, Brittany L. Bychkovsky, Gilberto de Lima Lopes Jr.
    Pages 257-266
  17. Monika K. Krzyzanowska, Melanie Powis
    Pages 267-286
  18. Allan A. Lima Pereira, Andre Deeke Sasse
    Pages 287-305
  19. Everardo D. Saad, Rachel P. Riechelmann
    Pages 307-314
  20. Bellinda L. King-Kallimanis, Roxanne E. Jensen, Laura C. Pinheiro, Diane L. Fairclough
    Pages 315-342
  21. Back Matter
    Pages 343-348

About this book


This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach.
Evidence-based medicine (EBM) has been in vogue in the last few decades, particularly in rapidly advancing fields such as oncology. This approach has been used to support decision-making processes worldwide, sparking new clinical research and guidelines on clinical and surgical oncology. Clinical oncology research has many peculiarities, including specific study endpoints, a special focus on survival analyses, and a unique perspective on EBM. However, during medical studies and in general practice, these topics are barely taught. Moreover, even when EBM and clinical cancer research are discussed, they are presented in a theoretical fashion, mostly focused on formulas and numbers, rather than on clinical application for a proper literature appraisal.
Addressing that gap, this book discusse
s more practical aspects of clinical research and biostatistics in oncology, instead of relying only on mathematical formulas and theoretical considerations. Methods and Biostatistics in Oncology will help readers develop the skills they need to understand the use of research on everyday oncology clinical practice for study design and interpretation, as well to demystify the use of EBM in oncology.


Oncology Clinical research Outcomes Biostatistics Research Methods Methodology

Editors and affiliations

  • Raphael. L.C Araújo
    • 1
  • Rachel P. Riechelmann
    • 2
  1. 1.Hospital do Câncer de BarretosBarretosBrazil
  2. 2.AC Camargo Cancer CenterDir - Brazil Gastrointestinal Tumor GrupSão PauloBrazil

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-71323-6
  • Online ISBN 978-3-319-71324-3
  • Buy this book on publisher's site