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Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

  • Book
  • © 2017


  • The first book to discuss gender biology and sex differences in endocrinology research and drug discovery for metabolic diseases
  • Expands on presentations and discussions at the March 2017 Keystone Symposium on this same topic
  • Foreword by Janine Clayton, MD, Director of NIH Office of Research on Women's Health
  • Includes supplementary material:

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1043)

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About this book

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases.

There are fundamental aspects of metabolic homeostasis that are regulated differently in males
and females, and influence boththe development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men. 

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Table of contents (28 chapters)

  1. Sex Differences in Diabetes and Obesity

  2. Role of Estrogens in Metabolic Homeostasis

Editors and Affiliations

  • Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, USA

    Franck Mauvais-Jarvis

About the editor

Franck Mauvais-Jarvis, MD, PhD, is Director of the Diabetes Discovery Research & Gender Medicine Laboratory, and Professor of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.

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