Allergy Prevention and Exacerbation

The Paradox of Microbial Impact on the Immune System

  • Carsten B. Schmidt-Weber

Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Fariza M. S. Badloe, Sherief R. Janmohamed, Johannes Ring, Jan Gutermuth
    Pages 11-26
  3. Gómez-Gascón Lidia, Barbara M. Bröker
    Pages 27-50
  4. Raphaela P. Semper, Markus Gerhard
    Pages 69-97
  5. Julia Esser-von Bieren
    Pages 99-120
  6. Rodrigo Jiménez-Saiz, Derek K. Chu, Susan Waserman, Manel Jordana
    Pages 121-144
  7. Caspar Ohnmacht
    Pages 145-165
  8. Marco Gargaro, Matteo Pirro, Giorgia Manni, Antonella De Luca, Teresa Zelante, Francesca Fallarino
    Pages 167-189
  9. Back Matter
    Pages 239-248

About this book


Allergy is developing into one of the most prevalent diseases affecting individuals in the very early days of life. While the cause of this epidemic is still unclear, it appears that the westernized life style is playing an important role, which includes nutrition, possibly air pollution as well as hygienic conditions. While epidemiologic studies were able to narrow down these factors, basic research discovered novel mechanisms that control the organism´s tolerance against allergens. Particularly interesting is the role of microorganisms that colonize or infect a host and thereby cause damage and immunological activation followed by sensitization or exacerbation of already existing sensitizations. However at the same time microbial activation of the immune system can help to generate a protective immunity that prevents allergen sensitization. The current book is collecting these evidences and connects epidemiologic and clinical mechanistic knowledge. Only the synthesis of this knowledge will help to find solutions to the ongoing allergy epidemic in terms of public health activities, prevention and therapy.


epidemiology of allergy hygiene hypothesis allergen tolerance genetic predisposition immunologic memory asthma exacerbation skin superinfection

Editors and affiliations

  • Carsten B. Schmidt-Weber
    • 1
  1. 1.ZAUMTechnical University of MunichMunichGermany

Bibliographic information