Handheld Total Chemical and Biological Analysis Systems

Bridging NMR, Digital Microfluidics, and Semiconductors

  • Ka-Meng Lei
  • Pui-In Mak
  • Man-Kay Law
  • Rui Paulo Martins

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Ka-Meng Lei, Pui-In Mak, Man-Kay Law, Rui Paulo Martins
    Pages 1-9
  3. Ka-Meng Lei, Pui-In Mak, Man-Kay Law, Rui Paulo Martins
    Pages 11-39
  4. Ka-Meng Lei, Pui-In Mak, Man-Kay Law, Rui Paulo Martins
    Pages 41-71
  5. Ka-Meng Lei, Pui-In Mak, Man-Kay Law, Rui Paulo Martins
    Pages 73-90
  6. Ka-Meng Lei, Pui-In Mak, Man-Kay Law, Rui Paulo Martins
    Pages 91-93
  7. Back Matter
    Pages 95-102

About this book

Introduction

The book Handheld Total Chemical and Biological Analysis Systems: Bridging NMR, Digital Microfluidics, and Semiconductorscenters on the complete design of Nuclear Magnetic Resonance (NMR) microsystems for in vitro chemical and biological assays based on semiconductor chips and portable magnet. Different sensing mechanisms for CMOS in vitro assay are compared, key design criteria of the CMOS transceiver for NMR measurement are revealed, and system-level optimizations of the CMOS NMR platform utilizing digital microfluidic and diverse functions of the CMOS technology are discussed. Two CMOS NMR platforms are implemented, each of these focuses on different aspect of optimization.

  • Shows literature review about state-of-the-art CMOS in vitro diagnosis systems and their sensing mechanisms;
  • Shows brief physics background on biological sensing with NMR;
  • Shows detailed design of the CMOS transceiver for NMR experiments;
  • Describes the first CMOS NMR platform integrated with digital microfluidic devices for electronic-automated sample management;
  • Demonstrates magnetic field stabilization for the portable magnet to enhance the robustness of the NMR platform with the aid of CMOS vertical Hall sensor.

Keywords

Smart Sensor Systems Bio/CMOS Biomedical CMOS ICs CMOS Biomicrosystems Bio MEMS

Authors and affiliations

  • Ka-Meng Lei
    • 1
  • Pui-In Mak
    • 2
  • Man-Kay Law
    • 3
  • Rui Paulo Martins
    • 4
  1. 1.State-Key Laboratory of Analog and Mixed-Signal VLSIUniversity of MacauMacauChina
  2. 2.State-Key Laboratory of Analog and Mixed-Signal VLSI and FST-ECEUniversity of MacauMacauChina
  3. 3.State-Key Laboratory of Analog and Mixed-Signal VLSIUniversity of MacauMacauChina
  4. 4.State-Key Laboratory of Analog and Mixed-Signal VLSI and FST-ECEUniversity of MacauMacauChina

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-67825-2
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Engineering
  • Print ISBN 978-3-319-67824-5
  • Online ISBN 978-3-319-67825-2
  • About this book