© 2018

Quantification of Biophysical Parameters in Medical Imaging

  • Ingolf Sack
  • Tobias Schaeffter

Table of contents

  1. Front Matter
    Pages i-viii
  2. Biological and Physical Fundamentals

    1. Front Matter
      Pages 7-7
    2. Sebastian Hirsch, Tobias Schaeffter, Ingolf Sack
      Pages 9-43
    3. Alfonso Caiazzo, Irene E. Vignon-Clementel
      Pages 45-70
    4. Hans Kubitschke, Erik W. Morawetz, Josef A. Käs, Jörg Schnauß
      Pages 89-121
    5. Angela Ariza de Schellenberger, Judith Bergs, Ingolf Sack, Matthias Taupitz
      Pages 123-150
  3. Medical Imaging Technologies

    1. Front Matter
      Pages 151-151
    2. Gitta Kutyniok, Jackie Ma, Maximilian März
      Pages 153-166
    3. Christoph Kolbitsch, Tobias Schaeffter
      Pages 167-186
    4. Sebastian Schmitter, Susanne Schnell
      Pages 187-212
    5. Martin Kunth, Leif Schröder
      Pages 213-253
    6. Ulrich Abram
      Pages 255-279
    7. Heiko Tzschätzsch
      Pages 281-302
  4. Applications

    1. Front Matter
      Pages 341-341
    2. Julia Brangsch, Carolin Reimann, Marcus R. Makowski
      Pages 373-381

About this book


This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.


Quantitative medical imaging Biophysical tissue properties Medical technology Parameter mapping Imaging technology Biophysics-based medical imaging markers Imaging biomarkers Imaging physics Medical image processing

Editors and affiliations

  • Ingolf Sack
    • 1
  • Tobias Schaeffter
    • 2
  1. 1.Department of RadiologyHumboldt University of Berlin Charité University HospitalBerlinGermany
  2. 2.Medical Physics and Metrological Information TechnologyPhysikalisch-Technische Bundesanstalt BerlinGermany

About the editors

Ingolf Sack is a Heisenberg professor of the German Research Foundation for Experimental Radiology and Elastography at Charité-Universitätsmedizin Berlin, Germany. He received a PhD in Chemistry from Freie Universität Berlin for the development of methods in NMR spectroscopy. He then worked at the Weizmann Institute in Rehovot, Israel and at the Sunnybrook Hospital, Toronto. Since 2003 he has led an interdisciplinary team of physicists, engineers, chemists, and physicians who have pioneered pivotal developments in time-harmonic elastography of both MRI and ultrasound for many medical applications.

Tobias Schaeffter is the head of divison of Medical Physics and metrological IT at the Physikalisch-Technische Bundesanstalt (PTB) in Berlin, Germany. He is also Professor in Imaging Sciences at the department of biomedical engineering at King’s College London, UK. Tobias Schaeffter studied electrical engineering at TU-Berlin and did his PhD in magnetic resonance spectroscopic imaging (MRSI) under supervision of Prof. Leibfritz at University Bremen in 1996. From 1996-2006, he worked as a Principal Scientist at the Philips Research Laboratories in Hamburg, Germany, where he managed MR-research projects , their clinical evaluation and product integration. In April 2006, he took up the Philip Harris Professorship of Imaging Sciences at King’s College London. In 2012 he became department head of biomedical engineering and was director of the doctorial training centre in medical imaging. Since 2015 he moved to  PTB as a head of divison. A major aim of his research is the investigation of fast and quantitative MR-techniques for cardiovascular applications. 

Bibliographic information