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D-type Cyclins and Cancer

  • Philip W. Hinds
  • Nelson E. Brown

Part of the Current Cancer Research book series (CUCR)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Charles J. Sherr, Peter Sicinski
    Pages 1-26
  3. Gabriele Di Sante, Mathew C. Casimiro, Zhiping Li, Adam Ertel, Peter Tompa, Richard G. Pestell
    Pages 61-90
  4. Claudio Valenzuela, Nelson E. Brown
    Pages 111-131
  5. Back Matter
    Pages 149-152

About this book

Introduction

This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.

Keywords

D1-S transition cyclin protein human tumors oncogenes tumorigenesis

Editors and affiliations

  • Philip W. Hinds
    • 1
  • Nelson E. Brown
    • 2
  1. 1.Tufts University School of MedicineBostonUSA
  2. 2.University of Talca Medical SchoolTalcaChile

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-64451-6
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-64449-3
  • Online ISBN 978-3-319-64451-6
  • Series Print ISSN 2199-2584
  • Series Online ISSN 2199-2592
  • Buy this book on publisher's site