Overview
- Nominated as an outstanding PhD thesis by the University of York, UK
- Demonstrates the first integration of silicon photonics with electrochemistry to yield a single, innovative and powerful technology
- Includes discussion of the key findings that were published in Nature Communications
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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About this book
This highly interdisciplinary thesis reports on two innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach’s ability to study molecular conformation and conformational changes in real time is demonstrated.
The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed bysimultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.
The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed bysimultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.
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Table of contents (7 chapters)
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Front Matter
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Back Matter
Authors and Affiliations
Bibliographic Information
Book Title: Dual-Mode Electro-photonic Silicon Biosensors
Authors: José Juan Colás
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-319-60501-2
Publisher: Springer Cham
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2017
Hardcover ISBN: 978-3-319-60500-5Published: 27 July 2017
Softcover ISBN: 978-3-319-86872-1Published: 04 August 2018
eBook ISBN: 978-3-319-60501-2Published: 18 July 2017
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XV, 149
Number of Illustrations: 16 b/w illustrations, 89 illustrations in colour
Topics: Biological and Medical Physics, Biophysics, Optical and Electronic Materials, Electrochemistry, Measurement Science and Instrumentation, Surface and Interface Science, Thin Films