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DNA and Histone Methylation as Cancer Targets

  • Book
  • © 2017

Overview

Editors:
  1. Atsushi Kaneda

    1. Graduate School of Medicine, Chiba University, Chiba, Japan

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  2. Yu-ichi Tsukada

    1. Advanced Biological Information Research Division, INAMORI Frontier Research Center, Kyushu University, Fukuoka, Japan

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    You can also search for this editor in PubMed   Google Scholar

  • Describes the features of DNA and histone methylation associated with particular types of cancer
  • Compiles the current knowledge of the molecular basis of DNA and histone methylation and contextualizes it within cancer
  • Presents analysis methods, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-viii
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  2. DNA and Histone Methylation in Epigenetics

    • Hengbin Wang, Jinrong Min, Trygve Tollefsbol
    Pages 1-15

  3. DNA Methylation and Cancer

    1. Front Matter

      Pages 17-17
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    2. The Molecular Basis of DNA Methylation

      • Isao Suetake, Mikio Watanebe, Kohei Takeshita, Saori Takahashi, Peter Carlton
      Pages 19-51

    3. The Molecular Basis of DNA Demethylation

      • Miao Shi, Li Shen
      Pages 53-73

    4. DNA Methylation Changes in Cancer

      • John P. Thomson, Richard R. Meehan
      Pages 75-96

    5. Misregulation of DNA Methylation Regulators in Cancer

      • Joyce J. Thompson, Keith D. Robertson
      Pages 97-124

  4. Histone Methylation and Cancer

    1. Front Matter

      Pages 125-125
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    2. The Molecular Basis of Histone Methylation

      • Lidong Sun, Jia Fang
      Pages 127-150

    3. The Molecular Basis of Histone Demethylation

      • John R. Horton, Molly Gale, Qin Yan, Xiaodong Cheng
      Pages 151-219

    4. Misregulation of Histone Methylation Regulators in Cancer

      • Wen Fong Ooi, Xiaosai Yao, Patrick Tan, Bin Tean Teh
      Pages 221-248

    5. Other Histone Modifications

      • Hiroaki Kato
      Pages 249-277

  5. DNA and Histone Methylation-Related Events Underlying Cancer

    1. Front Matter

      Pages 279-279
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    2. DNA Methylation and Dysregulation of miRNA in Cancer

      • Akira Kurozumi, Yusuke Goto, Atsushi Okato, Naohiko Seki
      Pages 281-296

    3. Genomic Imprinting Syndromes and Cancer

      • Ken Higashimoto, Keiichiro Joh, Hidenobu Soejima
      Pages 297-344

  6. DNA and Histone Methylation in Particular Types of Cancer

    1. Front Matter

      Pages 345-345
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    2. DNA and Histone Methylation in Brain Cancer

      • Sung-Hun Lee, Young Zoon Kim
      Pages 347-376

    3. DNA and Histone Methylation in Gastric Cancer

      • Keisuke Matsusaka, Atsushi Kaneda
      Pages 377-390

    4. DNA and Histone Methylation in Hematopoietic Malignancy

      • Kimihito Cojin Kawabata, Toshio Kitamura
      Pages 391-401

    5. DNA and Histone Methylation in Lung Cancer

      • Sophia Mastoraki, Evi Lianidou
      Pages 403-436
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Keywords

About this book

This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

Editors and Affiliations

  • Graduate School of Medicine, Chiba University, Chiba, Japan

    Atsushi Kaneda

  • Advanced Biological Information Research Division, INAMORI Frontier Research Center, Kyushu University, Fukuoka, Japan

    Yu-ichi Tsukada

About the editors

Atsushi Kaneda, MD, PhD, is Professor, Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Yu-ichi Tsukada, PhD, is Professor, Advanced Biological Information Research Division, INAMORI Frontier Research Center, Kyushu University, Fukuoka, Fukuoka, Japan

Bibliographic Information

  • Book Title: DNA and Histone Methylation as Cancer Targets

  • Editors: Atsushi Kaneda, Yu-ichi Tsukada

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-3-319-59786-7

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-59784-3Published: 12 September 2017

  • Softcover ISBN: 978-3-319-86700-7Published: 17 May 2018

  • eBook ISBN: 978-3-319-59786-7Published: 04 September 2017

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: VIII, 624

  • Number of Illustrations: 10 b/w illustrations, 81 illustrations in colour

  • Topics: Cancer Research

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