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Aqueous Two-Phase Systems for Bioprocess Development for the Recovery of Biological Products

  • Presents a comprehensive overview of the history and theoretical principles of Aqueous Two-Phase Systems
  • Addresses specific applications of ATPS for the recovery and partial purification of high molecular weight compounds, particulate bioproducts and low molecular weight compounds
  • Covers non-conventional strategies and economic analysis of the application of Aqueous Two-Phase Systems in comparison to other fractionation techniques

Part of the book series: Food Engineering Series (FSES)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-ix
  2. General Concepts and Definitions of Aqueous Two-Phase Systems

    • Karla Mayolo-Deloisa, Jorge Benavides, Marco Rito-Palomares
    Pages 1-18
  3. Characterization of Aqueous Two-Phase Systems and Their Potential New Applications

    • José González-Valdez, Jorge Benavides, Marco Rito-Palomares
    Pages 19-33
  4. Practical Aspects for the Development of ATPS-Based Processes for Protein Recovery

    • José González-Valdez, Karla Mayolo-Deloisa
    Pages 35-53
  5. Aqueous Two-Phase Systems for the Recovery of Bioparticles

    • Mirna González-González, Federico Ruiz-Ruiz
    Pages 55-78
  6. Aqueous Two-Phase System Strategies for the Recovery and Partial Purification of Bioactive Low Molecular Weight Compounds

    • Juan Carlos Sánchez-Rangel, Daniel A. Jacobo-Velázquez, Jorge Benavides
    Pages 79-96
  7. Affinity ATPS Strategies for the Selective Fractionation of Biomolecules

    • Federico Ruiz-Ruiz, Jorge Benavides, Marco Rito-Palomares
    Pages 97-121
  8. Continuous Aqueous Two-Phase System Processes

    • Patricia Vázquez-Villegas, Oscar Aguilar
    Pages 141-159
  9. Process Economics: Evaluation of the Potential of ATPS as a Feasible Alternative to Traditional Fractionation Techniques

    • Mario A. Torres-Acosta, Federico Ruiz-Ruiz, Jorge Benavides, Marco Rito-Palomares
    Pages 161-178
  10. Perspectives and Future Trends in Aqueous Two-Phase System-Based Technology

    • Jorge Benavides, Marco Rito-Palomares
    Pages 179-185
  11. Back Matter

    Pages 187-191

About this book

This comprehensive and unique text presents a full overview of downstream processing useful for those new to the concept as well as professionals with experience in the area. The history and theoretical principles of Aqueous Two-Phase Systems (ATPS) are covered in depth. Information on ATPS characterization and application is included, and ATPS equilibria and system parameters that have significant effect on partition behavior are studied.

Aqueous Two-Phase Systems for Bioprocess Development for the Recovery of Biological Products addresses specific applications of ATPS for the recovery and partial purification of high molecular weight compounds such as proteins, nucleic acids and polysaccharides, particulate bioproducts such as cells and organelles and low molecular weight compounds. Non-conventional strategies involving ATPS such as affinity systems, continuous liquid-liquid fractionation stages and the recovery from plant extracts are presented. Economic analysis of the application of ATPS in comparison to other fractionation techniques, particularly liquid chromatography, is considered, as are opportunity and current trends in the ATPS research area.

Each chapter utilizes the contributors' experimental expertise in traditional and non-conventional ATPS strategies, as well as analysis of areas of opportunity and perspectives on the development and future applications of ATPS in both the lab and larger scale operations. The result is a thorough and singular overview of ATPS which has not been matched by any other text on the market. 

Editors and Affiliations

  • Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias Centro de Biotecnología-FEMSA, Monterrey, Mexico

    Marco Rito-Palomares

  • Tecnologico de Monterrey, Escuela de Medicina, Monterrey, Mexico

    Jorge Benavides

About the editors

Marco Rito-Palomares is a professor at Tecnologico de Monterrey in Mexico


Jorge Benavides is a professor at Tecnologico de Monterrey in Mexico

Bibliographic Information

  • Book Title: Aqueous Two-Phase Systems for Bioprocess Development for the Recovery of Biological Products

  • Editors: Marco Rito-Palomares, Jorge Benavides

  • Series Title: Food Engineering Series

  • DOI: https://doi.org/10.1007/978-3-319-59309-8

  • Publisher: Springer Cham

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-59308-1Published: 27 July 2017

  • Softcover ISBN: 978-3-319-86594-2Published: 11 September 2018

  • eBook ISBN: 978-3-319-59309-8Published: 18 July 2017

  • Series ISSN: 1571-0297

  • Series E-ISSN: 2628-8095

  • Edition Number: 1

  • Number of Pages: IX, 191

  • Number of Illustrations: 7 b/w illustrations, 20 illustrations in colour

  • Topics: Food Science, Organic Chemistry

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access