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Metal Allergy

From Dermatitis to Implant and Device Failure

  • Book
  • © 2018


  • Reviews metal allergens and sources of metal exposure
  • Describes common and uncommon allergic responses
  • Pays special attention to select patient populations
  • Meets the needs of a wide range of medical specialists

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Table of contents (44 chapters)

  1. Metal: Overview

  2. Metals, Skin, and the Immune System

  3. Common Sources of Metal Exposure


About this book

This volume opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, detailing allergic responses and paying special consideration to select patient populations. In the general population, the prevalence of metal allergy is high. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. Metal allergy may result in allergic contact dermatitis and systemic contact dermatitis, as well as several less common manifestations. Further, metal allergy has been associated with device failure and/or dermatitis following implantation of medical devices and dental implants. As metals are ubiquitous, this book will be indispensable for a wide range of clinicians and investigators. This handy reference will meet the needs of all health professionals and investigators who are interested in metal allergy and its diagnosis and management. 


“Metal Allergy is a tempting read for arthroplasty surgeons, especially metal-on-metal enthusiasts and those struggling with trunnionosis. The hardcover book is presented to the usual high Springer standard. Chapter authors are mostly from the USA and continental Europe. … This book will mainly be of interest to orthopaedic surgeons dealing with metal bearings.” (J. Brockwell, The Bone & Joint Journal, Vol. 100-B (11), November, 2018)

Editors and Affiliations

  • Department of Dermatology, Stanford University School of Medicine, Redwood City, USA

    Jennifer K Chen

  • Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

About the editors

Jennifer Chen is currently an assistant professor at Stanford University School of Medicine. She holds an MD from Johns Hopkins University and has completed a Howard Hughes Medical Institute fellowship at Stanford University School of Medicine. Dr. Chen has published 25 articles and authored 4 book chapters. Her areas of interest include allergic contact dermatitis and medical dermatology. She regularly delivers presentations at international meetings and has served as a consultant for the Women's Health and Contemporary Pediatrics magazines, GreatistReader's Digest, and the local news. 

Jacob Thyssen has worked in clinical dermatology for more than 10 years and holds PhD and DmSci degrees from the University of Copenhagen in Denmark, where he is currently an associate professor. He has authored 250 articles, 12 book chapters and 2 textbooks (on patch testing and filaggrin proteins). Dr. Thyssen has received international awards for his research, including the LEO Pharma Research Foundation for best investigator aged below 45 years in the Nordic countries. His research has focused on atopic and contact dermatitis, allergies, and the skin barrier. He has been a research fellow in the USA, visiting Harvard Medical School and UCSF. Dr. Thyssen is a regular speaker at international meetings. He enjoys treating patients with dermatitis and metal allergies on a daily basis in the Gentofte Clinic in Copenhagen, Denmark.



Bibliographic Information

  • Book Title: Metal Allergy

  • Book Subtitle: From Dermatitis to Implant and Device Failure

  • Editors: Jennifer K Chen, Jacob P. Thyssen

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-58502-4Published: 25 April 2018

  • Softcover ISBN: 978-3-030-09632-8Published: 16 December 2018

  • eBook ISBN: 978-3-319-58503-1Published: 13 April 2018

  • Edition Number: 1

  • Number of Pages: XVII, 578

  • Number of Illustrations: 20 b/w illustrations, 75 illustrations in colour

  • Topics: Dermatology, Allergology, Occupational Medicine/Industrial Medicine, Orthopedics, Cardiac Surgery

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