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  • © 2018

Metal Allergy

From Dermatitis to Implant and Device Failure


(view affiliations)
  • Reviews metal allergens and sources of metal exposure

  • Describes common and uncommon allergic responses

  • Pays special attention to select patient populations

  • Meets the needs of a wide range of medical specialists

Buying options

USD 84.99
Price excludes VAT (USA)
  • ISBN: 978-3-319-58503-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 109.99
Price excludes VAT (USA)
Hardcover Book
USD 159.00
Price excludes VAT (USA)

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Table of contents (44 chapters)

  1. Front Matter

    Pages i-xvii
  2. Metal: Overview

    1. Front Matter

      Pages 1-1
    2. Use of Metals in Our Society

      • C. Peter Cutler
      Pages 3-16
    3. Metals and Corrosion

      • Morten Stendahl Jellesen
      Pages 17-22
    4. Chromate Testing in Leather: EN ISO 17075

      • Ines Anderie, Kerstin Schulte
      Pages 31-38
  3. Metals, Skin, and the Immune System

    1. Front Matter

      Pages 55-55
    2. Penetration of Metals Through the Skin Barrier

      • Francesca Larese Filon
      Pages 67-74
    3. Innate Immune System Response in Metal Allergy: Toll-Like Receptors

      • Marc Schmidt, Matthias Goebeler
      Pages 75-84
    4. Acquired Immunity in Metal Allergy: T Cell Responses

      • Trine Hilkjær Petersen, Carsten Geisler, Charlotte Menné Bonefeld
      Pages 85-95
    5. Metal Allergy and Tolerance Development

      • Angela Rizzi, Eleonora Nucera, Domenico Schiavino
      Pages 97-105
    6. Assessment for Metal Allergy: Patch Testing

      • Radoslaw Spiewak
      Pages 107-124
    7. Assessment for Metal Allergy: In Vitro Assays

      • Thomas Rustemeyer
      Pages 125-133
  4. Common Sources of Metal Exposure

    1. Front Matter

      Pages 135-135
    2. Metals in Everyday Life

      • Carsten R. Hamann, Dathan Hamann
      Pages 137-162
    3. Metals in Tools and the Workplace

      • Vera Mahler
      Pages 163-175
    4. Metals in Cosmetics

      • Malgorzata M. Brzóska, Malgorzata Galażyn-Sidorczuk, Sylwia Borowska
      Pages 177-196
    5. Metals in Coins

      • Kelsey E. Hirotsu, Jennifer K. Chen
      Pages 197-209

About this book

This volume has been compiled in response to the ongoing revolution in our understanding of metal contact allergy, and the ensuing challenge this has created for clinicians and others to synthesize large amounts of sometimes contradictory data. It opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, and detailed sections are devoted to hypersensitivity to metal implants (which may be associated with device failure and/or dermatitis), metal allergy in select patient populations, and less frequently encountered manifestations of metal allergy.

The prevalence of metal allergy in the general population is high: up to 17% of people are allergic to nickel, and 1–3% to cobalt and chromium. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. As metals are ubiquitous, this book will be an indispensable reference text for a wide range of clinicians and investigators, meeting the needs of all who are interested in metal allergy and its diagnosis and management.




  • Metallic Implants
  • Allergic contact dermatitis
  • Nickel
  • Contact allergy
  • Patch testing
  • Metal exposure
  • Metal allergy


“Metal Allergy is a tempting read for arthroplasty surgeons, especially metal-on-metal enthusiasts and those struggling with trunnionosis. The hardcover book is presented to the usual high Springer standard. Chapter authors are mostly from the USA and continental Europe. … This book will mainly be of interest to orthopaedic surgeons dealing with metal bearings.” (J. Brockwell, The Bone & Joint Journal, Vol. 100-B (11), November, 2018)

Editors and Affiliations

  • Department of Dermatology, Stanford University School of Medicine, Redwood City, USA

    Jennifer K Chen

  • Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

About the editors

Jennifer Chen is currently an assistant professor at Stanford University School of Medicine. She holds an MD from Johns Hopkins University and has completed a Howard Hughes Medical Institute fellowship at Stanford University School of Medicine. Dr. Chen has published 25 articles and authored 4 book chapters. Her areas of interest include allergic contact dermatitis and medical dermatology. She regularly delivers presentations at international meetings and has served as a consultant for the Women's Health and Contemporary Pediatrics magazines, GreatistReader's Digest, and the local news. 

Jacob Thyssen has worked in clinical dermatology for more than 10 years and holds PhD and DmSci degrees from the University of Copenhagen in Denmark, where he is currently an associate professor. He has authored 250 articles, 12 book chapters and 2 textbooks (on patch testing and filaggrin proteins). Dr. Thyssen has received international awards for his research, including the LEO Pharma Research Foundation for best investigator aged below 45 years in the Nordic countries. His research has focused on atopic and contact dermatitis, allergies, and the skin barrier. He has been a research fellow in the USA, visiting Harvard Medical School and UCSF. Dr. Thyssen is a regular speaker at international meetings. He enjoys treating patients with dermatitis and metal allergies on a daily basis in the Gentofte Clinic in Copenhagen, Denmark.



Bibliographic Information

  • Book Title: Metal Allergy

  • Book Subtitle: From Dermatitis to Implant and Device Failure

  • Editors: Jennifer K Chen, Jacob P. Thyssen

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-58502-4

  • Softcover ISBN: 978-3-030-09632-8

  • eBook ISBN: 978-3-319-58503-1

  • Edition Number: 1

  • Number of Pages: XVII, 578

  • Number of Illustrations: 20 b/w illustrations, 75 illustrations in colour

  • Topics: Dermatology, Allergology, Occupational Health, Orthopaedics, Cardiac Surgery

Buying options

USD 84.99
Price excludes VAT (USA)
  • ISBN: 978-3-319-58503-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 109.99
Price excludes VAT (USA)
Hardcover Book
USD 159.00
Price excludes VAT (USA)