Overview
- Informative and authoritative, this book presents state-of-the-art strategies for CTC research from experts and key opinion leaders in the field
- This book contains creative and innovative ideas for rare-cell detection and isolation
- This book offers comprehensive discussions on the current understanding of the molecular biology of CTCs, as well as highly advanced and in-depth approaches for molecular characterization of these cells
- TThis book includes discussions on the potential clinical utility of CTCs and how these cells may be incorporated into routine medical practice and personalized medicine
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 994)
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About this book
Numerous studies have shown that elevated levels of circulating tumor cells (CTCs) in blood of cancer patients are associated with poor response to treatment and inferior survival probabilities. Despite this clinical significance, the molecular biology of CTCs remains poorly understood. The paucity in molecular information can be attributed to the tremendous technical challenges involved in isolating these extremely rare cells. Recent technological advancements in rare-cell technology, however, have allowed for the reliable enrichment and isolation of CTCs. Consequently, the use of recently developed molecular approaches —e.g., multiplexed QPCR, microarray, and next generation sequencing analyses— to profile CTCs have provided novel insights into the molecular makeup of these tumor cells. This book discusses approaches for enrichment and isolation of CTCs as well as recent advances in comprehensive molecular profiling of CTCs using cutting-edge omics technology.
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Table of contents (16 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Isolation and Molecular Characterization of Circulating Tumor Cells
Editors: Mark Jesus M. Magbanua, John W. Park
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-55947-6
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017
Hardcover ISBN: 978-3-319-55946-9Published: 08 June 2017
Softcover ISBN: 978-3-319-85787-9Published: 02 August 2018
eBook ISBN: 978-3-319-55947-6Published: 29 May 2017
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XVI, 301
Number of Illustrations: 27 b/w illustrations, 15 illustrations in colour
Topics: Cancer Research