Mechanisms of Molecular Carcinogenesis – Volume 1

1. Front Matter

   Pages i-viii

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2. The Endocannabinoid System in Carcinogenesis

   • Rudolf Schicho

   Pages 1-10

3. MACC1, a Novel Player in Solid Cancer Carcinogenesis

   • Giridhar Mudduluru, Katharina Ilm, Mathias Dahlmann, Ulrike Stein

   Pages 11-38

4. Axl and Its Mediated Signaling Axis in Cancer

   • Giridhar Mudduluru

   Pages 39-60

5. Insulin Signaling Linking Metabolism and Malignancy

   • Sonja M. Kessler, Alexandra K. Kiemer

   Pages 61-75

6. Translational Control and mTOR in Cancer

   • Rita Seeböck, Nicole Golob-Schwarzl, Stefanie Krassnig

   Pages 77-86

7. NF-κB and Its Implication in Liver Health and Cancer Development

   • Kira Bettermann

   Pages 87-114

8. Molecular Carcinogenesis of Glial Brain Tumors

   • Peter Strasser, Serge Weis

   Pages 115-136

9. Molecular Carcinogenesis of Non-glial Brain Tumors

   • Serge Weis, Peter Strasser

   Pages 137-150

10. Molecular Carcinogenesis of Uveal Melanoma

    • Werner Wackernagel, Lisa Tarmann, Gerald Langmann, Arun D. Singh

    Pages 151-174

11. Molecular Aspects of Thyroid Carcinogenesis

    • Rita Seeböck, Johannes Haybaeck, Oleksiy Tsybrovskyy

    Pages 175-184

12. Carcinogenesis in the Epithelium of the Upper Aerodigestive Tract

    • Dietmar Thurnher

    Pages 185-190

13. Carcinogenesis of Sinonasal Carcinomas

    • P. V. Tomazic

    Pages 191-197

14. Parotid Cancer

    • Axel Wolf

    Pages 199-204

15. Carcinogenesis of Laryngeal Tumors

    • G. P. Hammer

    Pages 205-223

16. Photodynamic Therapy for Esophageal Cancer: Functional, Clinical, and Immunological Aspects

    • Joerg Lindenmann, Nicole Fink-Neuboeck

    Pages 225-250

17. Biomarkers for Predicting Neoplastic Progression in Barrett’s Esophagus

    • F. Durchschein, G. Absenger

    Pages 251-269

18. The Role of Macrophages Within Microenvironment in a Lung Cancer Development and Progression

    • Luka Brčić, Luka Opašić, Helmut Popper

    Pages 271-285

19. Progression of Lung Cancer: Role of Hypoxia and the Metabolic Tumor Microenvironment

    • Katharina Leithner, Horst Olschewski

    Pages 287-299

Divided into two volumes the work offers a so far unmatched broad and at the same time deep knowledge on molecular and cellular mechanisms of carcinogenesis and offers comprehensive insight into clinical, therapeutic and technological aspects. This 1st Volume presents tumor entities of the ocular system, the thyroid organ, the oesophagus, gliomas, non-glial brain tumors, head and neck as well as lung cancer. In addition it also discusses in-depth potential novel molecular players and the role of stem cells as well as the endocannabinoid system in carcinogenesis, it furthermore explains tumor metabolism components and signaling pathways. Each of the chapters discusses potential therapeutic strategies and novel drug targets.

The book addresses basic scientists and medical researchers interested in translational cancer research.

• cancer biomarkers
• mechanism of carcinogenesis
• molecular cancer diagnostics
• molecular cancer profile
• targeted cancer therapy
• translational cancer research
• gene expression

• Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany

  Johannes Haybaeck

Prof. Johannes Haybaeck is a professor of Pathology at the Department of Pathology, Medical Faculty of the University of Magdeburg, Germany. He is a board certified pathologist and neuropathologist who is also specialized in molecular biology. Prof. Haybaeck received his first degree in Medicine at Innsbruck University, Austria, prior to further studies at the University of Zurich, Innsbruck and Salzburg. He received his PhD degree at the Mathematical and Natural Science Faculty of the University of Zurich. Since 2010, he has led his own research group and has been a consultant for pathology and neuropathology.  In 2011, he was nominated as Vice Chair, and since 2014, he has held the title of Chairman of the Department of Neuropathology at the Medical University of Graz, Austria. He was elected as Founding Coordinator for Cancer Research, Education and Training of the Comprehensive Cancer Center (CCC) Graz for two periods. In 2016, he was nominated as Full Professor and Head of the Department of Pathology at Magdeburg University Hospital in Germany. In his capacity as a surgical pathologist and neuropathologist, he is confronted with diagnostic questions on a daily basis. Accordingly, his research focuses on the cellular and molecular mechanisms driving carcinogenesis. Together with his coworkers in Magdeburg and Graz, he is constantly engaged in the development of novel models mimicking the human situation in order to establish prognostic and predictive biomarkers and to generate novel therapies.

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