Leucine-Rich Repeat Kinase 2 (LRRK2)

  • Hardy J. Rideout

Part of the Advances in Neurobiology book series (NEUROBIOL, volume 14)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Clinical and Genetic Considerations of LRRK2 Associated Parkinson’s Disease

    1. Front Matter
      Pages 1-1
    2. Edoardo Monfrini, Alessio Di Fonzo
      Pages 3-30
    3. Meir Kestenbaum, Roy N. Alcalay
      Pages 31-48
  3. Fundamentals of LRRK2 Biology

    1. Front Matter
      Pages 49-49
    2. R. Jeremy Nichols
      Pages 51-70
    3. Claudia Manzoni, Patrick A. Lewis
      Pages 89-105
    4. Laura Civiero, Isabella Russo, Luigi Bubacco, Elisa Greggio
      Pages 107-121
    5. Nicolas L. Dzamko
      Pages 123-143
    6. Jean-Marc Taymans
      Pages 145-160
  4. LRRK2 Neurodegeneration, Modeling, and Therapeutic Options

    1. Front Matter
      Pages 161-161
    2. Yulan Xiong, Ted M. Dawson, Valina L. Dawson
      Pages 163-191
    3. Mark R. Cookson
      Pages 227-239
    4. John M. Hatcher, Hwan Geun Choi, Dario R. Alessi, Nathanael S. Gray
      Pages 241-264
  5. Back Matter
    Pages 265-271

About this book

Introduction

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Keywords

GTPase Parkinson's Disease kinase neurodegeneration signaling

Editors and affiliations

  • Hardy J. Rideout
    • 1
  1. 1.Biomedical Research Foundation of the Academy of Athens (BRFAA)AthensGreece

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-49969-7
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-49967-3
  • Online ISBN 978-3-319-49969-7
  • Series Print ISSN 2190-5215
  • Series Online ISSN 2190-5223
  • About this book