© 2016

How to Overcome the Antibiotic Crisis

Facts, Challenges, Technologies and Future Perspectives

  • Marc Stadler
  • Petra Dersch

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 398)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Eva Medina, Dietmar Helmut Pieper
    Pages 3-33
  3. Jaishri Mehraj, Wolfgang Witte, Manas K. Akmatov, Franziska Layer, Guido Werner, Gérard Krause
    Pages 55-87
  4. Klaus Hornischer, Susanne Häußler
    Pages 89-102
  5. Sabrina Mühlen, Petra Dersch
    Pages 147-183
  6. Kai Schulze, Thomas Ebensen, Peggy Riese, Blair Prochnow, Claus-Michael Lehr, Carlos A. Guzmán
    Pages 207-234
  7. Kathrin I. Mohr
    Pages 237-272
  8. Jennifer Herrmann, Tadeja Lukežič, Angela Kling, Sascha Baumann, Stephan Hüttel, Hrvoje Petković et al.
    Pages 339-363
  9. Markus Kalesse, Andreas Böhm, Andi Kipper, Vanessa Wandelt
    Pages 419-445
  10. Thomas Hesterkamp
    Pages 447-474
  11. Florian Graef, Sarah Gordon, Claus-Michael Lehr
    Pages 475-496

About this book


This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.


Antibiotic resistance Multidrug-resistant bacteria Antimicrobial resistance Group B streptococci Gut microbiota Multi-resistant bacteria Anti-virulence strategies Needle-free immunization strategies Novel antibiotics Antimicrobial drug research

Editors and affiliations

  • Marc Stadler
    • 1
  • Petra Dersch
    • 2
  1. 1.Department Microbial DrugsHelmholtz Centre for Infection ResearchBraunschweigGermany
  2. 2.Dept. Molecular Infection BiologyHelmholtz Centre for Infection ResearchBraunschweigGermany

About the editors

Prof. Dr. Marc Stadler and Prof. Dr. Petra Dersch
Helmholtz Centre for Infection Research, Braunschweig, Germany

Bibliographic information