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  • © 2017

Vertebrate Development

Maternal to Zygotic Control

  • Emphasizes underlying common molecular, cellular and developmental themes between vertebrates and pro-vertebrates

  • Uniquely focuses on the very earliest stages of development, at the transition between information provided by the mother in the egg and the regulation by genetic material of the embryo

  • Discusses nuclear transfer, a promising new tool with applications to regenerative medicine and conservation biology?

  • Includes supplementary material:

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 953)

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eBook USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-46095-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 199.99
Price excludes VAT (USA)
Hardcover Book USD 279.99
Price excludes VAT (USA)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
  2. Egg Activation at Fertilization

    • Zoltan Machaty, Andrew R. Miller, Lu Zhang
    Pages 1-47
  3. Controlling the Messenger: Regulated Translation of Maternal mRNAs in Xenopus laevis Development

    • Michael D. Sheets, Catherine A. Fox, Megan E. Dowdle, Susanne Imboden Blaser, Andy Chung, Sookhee Park
    Pages 49-82
  4. Regulation of Cell Division

    • Andreas Heim, Beata Rymarczyk, Thomas U. Mayer
    Pages 83-116
  5. Vertebrate Embryonic Cleavage Pattern Determination

    • Andrew Hasley, Shawn Chavez, Michael Danilchik, Martin Wühr, Francisco Pelegri
    Pages 117-171
  6. Localization in Oogenesis of Maternal Regulators of Embryonic Development

    • Matias Escobar-Aguirre, Yaniv M. Elkouby, Mary C. Mullins
    Pages 173-207
  7. Vertebrate Axial Patterning: From Egg to Asymmetry

    • Douglas W. Houston
    Pages 209-306
  8. Establishment of the Vertebrate Germ Layers

    • Wei-Chia Tseng, Mumingjiang Munisha, Juan B. Gutierrez, Scott T. Dougan
    Pages 307-381
  9. Mechanisms of Vertebrate Germ Cell Determination

    • Tristan Aguero, Susannah Kassmer, Ramiro Alberio, Andrew Johnson, Mary Lou King
    Pages 383-440
  10. Cell Cycle Remodeling and Zygotic Gene Activation at the Midblastula Transition

    • Maomao Zhang, Jennifer Skirkanich, Michael A. Lampson, Peter S. Klein
    Pages 441-487
  11. Clearance of Parental Products

    • Petr Svoboda, Helena Fulka, Radek Malik
    Pages 489-535
  12. Erratum

    • Francisco Pelegri, Michael Danilchik, Ann Sutherland
    Pages E1-E1Open Access
  13. Back Matter

    Pages 537-549

About this book

This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems.  It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition to their fundamental scientific interest, many frontiers of biomedicine, such as reproductive biology, stem cells and reprogramming, and the understanding of intergenerational diseases, depend on advances in our knowledge of these early processes. Vertebrate Development: Maternal to Zygotic Control brings together chapters from experts in various disciplines describing the latest advances related to this important developmental transition. Each chapter is a synthesis of knowledge relevant to all vertebrates, with details on specific systems as well as comparisons between the various studied vertebrate models. The editorial expertise encompasses the fields of major vertebrate model systems (mammalian, amphibian and teleost) ensuring a balanced approach to various topics. This unique book—with its combination of in-depth and up-to-date basic research, inter-species comprehensiveness and emphasis on the very early stages of animal development—is essential for research scientists studying vertebrate development, as well as being a valuable resource for college educators teaching advanced courses in developmental biology.


  • cell division
  • egg-to-embryo
  • midblastula
  • fertilization
  • embryonic development

Editors and Affiliations

  • Laboratory of Genetics, University of Wisconsin—Madison, Madison, USA

    Francisco Pelegri

  • Department of Integrative Biosciences, Oregon Health & Science University, Portland, USA

    Michael Danilchik

  • Department of Cell Biology, University of Virginia Health System, Charlottesville, USA

    Ann Sutherland

About the editors

Dr. Francisco Pelegri is currently a Professor in the Laboratory of Genetics at the University of Wisconsin-Madison. He received his PhD from the Massachusetts Institute of Technology and his postdoctoral position was at the Max Planck Institute for Developmental Biology, Tübingen, Germany. His research focus is understanding at the cellular and molecular level processes involved in early zebrafish development, specifically but not exclusively the functional diversification of cell types.

Dr. Michael V. Danilchik is a Professor in the Department of Integrative Biosciences at Oregon Health & Science University. He received his PhD from the University of Washington and did his postdoctoral training at the University of California, Berkeley. His research interest is in cellular mechanisms of pregastrular morphogenesis, particularly cytoskeletal and membrane dynamics during cleavage-stage cytokinesis, and long-range cell-cell signaling modalities involving filopodia and extracellular vesicles.

Dr. Ann E. Sutherland is an Associate Professor, Cell Biology at the School of Medicine at University of Virginia. She earned her PhD at the University of California San Francisco. Her laboratory’s research focuses primarily on the cellular mechanisms of implantation and gastrulation in the mouse embryo and, in particular, the regulation of motility in the trophoblast cells of the implanting mouse blastocyst, and the cell behaviors leading to axial elongation in the mid-gestation embryo.

Bibliographic Information

  • Book Title: Vertebrate Development

  • Book Subtitle: Maternal to Zygotic Control

  • Editors: Francisco Pelegri, Michael Danilchik, Ann Sutherland

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2017

  • Hardcover ISBN: 978-3-319-46093-2

  • Softcover ISBN: 978-3-319-83439-9

  • eBook ISBN: 978-3-319-46095-6

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 549

  • Number of Illustrations: 10 b/w illustrations, 71 illustrations in colour

  • Topics: Cell Biology, Embryology

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-46095-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 199.99
Price excludes VAT (USA)
Hardcover Book USD 279.99
Price excludes VAT (USA)