Skip to main content
  • Book
  • © 2017

The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease

Cushing’s Syndrome and Beyond

Editors:

(view affiliations)
  • Explores recent advances in the development of novel medical therapies for the treatment of Cushing’s syndrome

  • Provides valuable and cutting edge perspectives on these topics including the concept of “subclinical” adrenal Cushing’s syndrome

  • Reviews the pathophysiology of excess cortisol on body composition and metabolism, in particular adipose tissue and bone

  • Includes supplementary material: sn.pub/extras

Buying options

eBook
USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-45950-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 139.99
Price excludes VAT (USA)
Hardcover Book
USD 199.99
Price excludes VAT (USA)

This is a preview of subscription content, access via your institution.

Table of contents (15 chapters)

  1. Front Matter

    Pages i-vi
  2. Hypothalamic-Pituitary-Adrenal Axis Regulation of the Body, Brain, and Inflammation

    1. Front Matter

      Pages 1-1
    2. Glucocorticoid Regulation of Body Composition and Metabolism

      • Alexandria Atuahene Opata, Khadeen C. Cheesman, Eliza B. Geer
      Pages 3-26
    3. Glucocorticoid Regulation of Neurocognitive and Neuropsychiatric Function

      • Alberto M. Pereira, Onno C. Meijer
      Pages 27-41
    4. Glucocorticoids: Inflammation and Immunity

      • Maria G. Petrillo, Carl D. Bortner, John A. Cidlowski
      Pages 43-63
  3. Cushing’s Syndrome

    1. Front Matter

      Pages 65-65
    2. Molecular Pathogenesis of Primary Adrenal Cushing’s Syndrome

      • Nada El Ghorayeb, Isabelle Bourdeau, André Lacroix
      Pages 67-92
    3. Imaging Strategies for Localization of ACTH-Secreting Tumors

      • Lynnette K. Nieman, Ahmed M. Gharib
      Pages 137-148
    4. Surgical Treatment of Cushing’s Disease

      • Hekmat Zarzour, Margaret Pain, Joshua Bederson, Kalmon D. Post
      Pages 149-164
    5. Medical Therapies in Cushing’s Syndrome

      • Nicholas A. Tritos, Beverly M. K. Biller
      Pages 165-179
    6. Mild Adrenal Cortisol Excess

      • Adina F. Turcu, Richard J. Auchus
      Pages 181-197
    7. Long-Term Effects of Prior Cushing’s Syndrome

      • Anna Aulinas, Elena Valassi, Eugenia Resmini, Alicia Santos, Iris Crespo, María-José Barahona et al.
      Pages 199-224
    8. Cushing’s Disease, Refining the Definition of Remission and Recurrence

      • Jeremy N. Ciporen, Justin S. Cetas, Shirley McCartney, Maria Fleseriu
      Pages 225-252
  4. Beyond Cushing’s: Glucocorticoid Sensitivity, Regulation, and the Metabolic Syndrome

    1. Front Matter

      Pages 253-253
    2. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor

      • Nicolas C. Nicolaides, Agaristi Lamprokostopoulou, Amalia Sertedaki, George P. Chrousos, Evangelia Charmandari
      Pages 255-269
    3. Cortisol Metabolism as a Regulator of the Tissue-Specific Glucocorticoid Action

      • Emilia Sbardella, Jeremy W. Tomlinson
      Pages 271-301
    4. Obesity and Metabolic Syndrome: A Phenotype of Mild Long-Term Hypercortisolism?

      • Vincent L. Wester, Elisabeth F. C. van Rossum
      Pages 303-313
  5. Back Matter

    Pages 315-327

About this book

Cushing´s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing’s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing’s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.

Keywords

  • HPA axis
  • adrenal
  • cortisol
  • metabolic disorders
  • neuroendocrine
  • pathophysiology
  • Systems Biology

Editors and Affiliations

  • Division of Endocrinology, Multidisciplinary Pituitary and Skull Base Tumor Center, Memorial Sloan Kettering Cancer Center, New York, USA

    Eliza B. Geer

About the editor

Eliza B. Geer, MD is an endocrinologist at Mount Sinai Medical Center in the Division of Endocrinology with a secondary appointment in the Department of Neurosurgery. After graduating from Columbia University, she attended Mount Sinai School of Medicine, graduating in 2006. Dr. Geer's clinical and research interests include pituitary diseases and neuroendocrinology. She is the principal investigator of a number of studies investigating body composition, adipose tissue regulation, appetite, and long term outcomes in patients with Cushing's Disease and other pituitary diseases. She was awarded the Dr. Harold and Golden Lamport Research Award for Clinical Research in 2012, and the Mount Sinai Endocrinologist of the Year award for outstanding service to the Icahn School of Medicine and Mount Sinai Hospital in 2013.

Bibliographic Information

  • Book Title: The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease

  • Book Subtitle: Cushing’s Syndrome and Beyond

  • Editors: Eliza B. Geer

  • DOI: https://doi.org/10.1007/978-3-319-45950-9

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2017

  • Hardcover ISBN: 978-3-319-45948-6

  • Softcover ISBN: 978-3-319-83405-4

  • eBook ISBN: 978-3-319-45950-9

  • Edition Number: 1

  • Number of Pages: VI, 327

  • Number of Illustrations: 4 b/w illustrations, 15 illustrations in colour

  • Topics: Endocrinology, Computational and Systems Biology

Buying options

eBook
USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-45950-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 139.99
Price excludes VAT (USA)
Hardcover Book
USD 199.99
Price excludes VAT (USA)