Overview
- Editors:
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Eliza B. Geer
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Division of Endocrinology, Multidisciplinary Pituitary and Skull Base Tumor Center, Memorial Sloan Kettering Cancer Center, New York, USA
Explores recent advances in the development of novel medical therapies for the treatment of Cushing’s syndrome
Provides valuable and cutting edge perspectives on these topics including the concept of “subclinical” adrenal Cushing’s syndrome
Reviews the pathophysiology of excess cortisol on body composition and metabolism, in particular adipose tissue and bone
Includes supplementary material: sn.pub/extras
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Table of contents (15 chapters)
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Hypothalamic-Pituitary-Adrenal Axis Regulation of the Body, Brain, and Inflammation
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- Alexandria Atuahene Opata, Khadeen C. Cheesman, Eliza B. Geer
Pages 3-26
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- Alberto M. Pereira, Onno C. Meijer
Pages 27-41
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- Maria G. Petrillo, Carl D. Bortner, John A. Cidlowski
Pages 43-63
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Cushing’s Syndrome
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- Nada El Ghorayeb, Isabelle Bourdeau, André Lacroix
Pages 67-92
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- Yang Shen, Anthony P. Heaney
Pages 93-110
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- James W. Findling, Hershel Raff
Pages 111-136
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- Lynnette K. Nieman, Ahmed M. Gharib
Pages 137-148
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- Hekmat Zarzour, Margaret Pain, Joshua Bederson, Kalmon D. Post
Pages 149-164
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- Nicholas A. Tritos, Beverly M. K. Biller
Pages 165-179
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- Adina F. Turcu, Richard J. Auchus
Pages 181-197
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- Anna Aulinas, Elena Valassi, Eugenia Resmini, Alicia Santos, Iris Crespo, María-José Barahona et al.
Pages 199-224
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- Jeremy N. Ciporen, Justin S. Cetas, Shirley McCartney, Maria Fleseriu
Pages 225-252
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Beyond Cushing’s: Glucocorticoid Sensitivity, Regulation, and the Metabolic Syndrome
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Front Matter
Pages 253-253
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- Nicolas C. Nicolaides, Agaristi Lamprokostopoulou, Amalia Sertedaki, George P. Chrousos, Evangelia Charmandari
Pages 255-269
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- Emilia Sbardella, Jeremy W. Tomlinson
Pages 271-301
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- Vincent L. Wester, Elisabeth F. C. van Rossum
Pages 303-313
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Back Matter
Pages 315-327
About this book
Cushing´s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing’s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing’s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.
Editors and Affiliations
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Division of Endocrinology, Multidisciplinary Pituitary and Skull Base Tumor Center, Memorial Sloan Kettering Cancer Center, New York, USA
Eliza B. Geer
About the editor
Eliza B. Geer, MD is an endocrinologist at Mount Sinai Medical Center in the Division of Endocrinology with a secondary appointment in the Department of Neurosurgery. After graduating from Columbia University, she attended Mount Sinai School of Medicine, graduating in 2006. Dr. Geer's clinical and research interests include pituitary diseases and neuroendocrinology. She is the principal investigator of a number of studies investigating body composition, adipose tissue regulation, appetite, and long term outcomes in patients with Cushing's Disease and other pituitary diseases. She was awarded the Dr. Harold and Golden Lamport Research Award for Clinical Research in 2012, and the Mount Sinai Endocrinologist of the Year award for outstanding service to the Icahn School of Medicine and Mount Sinai Hospital in 2013.
