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  • © 2016

Intracellular Delivery III

Market Entry Barriers of Nanomedicines

Editors:

  1. Aleš Prokop

    1. Biomolecular and Chemical Engineering, Vanderbilt University Biomolecular and Chemical Engineering, Nashville, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Volkmar Weissig

    1. Pharmaceutical Sciences, Midwestern University Pharmaceutical Sciences, GLENDALE, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Comprehensive set of reviews dealing with cellular (tissue) and intracellular targeting of nanovehicles

  • Covers classical and computational means of nanovehicle targeting

  • Delivers important application areas in medicine

  • Written by world experts in this field

Part of the book series: Fundamental Biomedical Technologies (FBMT)

Sections

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  • ISBN: 978-3-319-43525-1
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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xiii
    PDF

  2. Introductory Chapters

    1. Front Matter

      Pages 1-1
      PDF

  3. EPR Effect and ECM Modification

    1. Front Matter

      Pages 47-47
      PDF

  4. How to Extend the Circulation Time of Nanovehicles

    1. Front Matter

      Pages 123-123
      PDF

  5. Differences Between In Vivo Status in Men and Mice

    1. Front Matter

      Pages 147-147
      PDF

  6. Cell-Specific Targeting

    1. Front Matter

      Pages 161-161
      PDF

    2. Ligand-targeted Particulate Nanomedicines Undergoing Clinical Evaluation: Current Status

      • Roy van der Meel, Laurens J. C. Vehmeijer, Robbert Jan Kok, Gert Storm, Ethlinn V. B. van Gaal
      Pages 163-200

    4. Accessing Mitochondrial Targets Using NanoCargos

      • Ru Wen, Afoma C. Umeano, Shanta Dhar
      Pages 229-254

    5. Redox-Responsive Nano-Delivery Systems for Cancer Therapy

      • Amit Singh, Thanh-Huyen Tran, Mansoor M. Amiji
      Pages 255-269

  7. Improved Imaging

    1. Front Matter

      Pages 271-271
      PDF

    2. Nano-emulsions for Drug Delivery and Biomedical Imaging

      • Nicolas Anton, François Hallouard, Mohamed F. Attia, Thierry F. Vandamme
      Pages 273-300

    4. Microscopic Mass Spectrometry for the Precise Design of Drug Delivery Systems

      • Yasuhiro Matsumura, Masahiro Yasunaga
      Pages 323-337
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About this book

A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes and most recently “nanomaterials” have been said to “show promise” but none of these promises have so far been “reduced” to human clinical practice. 
The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies. 
Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug–carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile. 

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Keywords

  • Biochemical targeting
  • Cellular (tissue) targeting
  • Computational means of target discovery
  • Discovery applicable for the Pharmaceutical industry
  • Discovery of targeting
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Editors and Affiliations

  • Biomolecular and Chemical Engineering, Vanderbilt University Biomolecular and Chemical Engineering, Nashville, USA

    Aleš Prokop

  • Pharmaceutical Sciences, Midwestern University Pharmaceutical Sciences, GLENDALE, USA

    Volkmar Weissig

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Bibliographic Information

  • Book Title: Intracellular Delivery III

  • Book Subtitle: Market Entry Barriers of Nanomedicines

  • Editors: Aleš Prokop, Volkmar Weissig

  • Series Title: Fundamental Biomedical Technologies

  • DOI: https://doi.org/10.1007/978-3-319-43525-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-43523-7Published: 23 December 2016

  • Softcover ISBN: 978-3-319-82846-6Published: 12 July 2018

  • eBook ISBN: 978-3-319-43525-1Published: 31 October 2016

  • Series ISSN: 1559-7083

  • Series E-ISSN: 2626-8655

  • Edition Number: 1

  • Number of Pages: XIII, 453

  • Number of Illustrations: 16 b/w illustrations, 65 illustrations in colour

  • Topics: Biomedical Research, Nanotechnology

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Access via your institution
eBook USD 169.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-43525-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 219.99
Price excludes VAT (USA)
Hardcover Book USD 219.99
Price excludes VAT (USA)
Learn about institutional subscriptions