About this book
This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.
The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.
Cancer Treatment Anti-tumor immune response Immogenic tumors Cancer-associated fibroblasts Cancer-associated Tertiary Lymphoid Structures Cancer immunotherapy Chemokines Chimeric antigen receptor
Editors and affiliations
- DOI https://doi.org/10.1007/978-3-319-42223-7
- Copyright Information Springer International Publishing Switzerland 2016
- Publisher Name Springer, Cham
- eBook Packages Biomedical and Life Sciences
- Print ISBN 978-3-319-42221-3
- Online ISBN 978-3-319-42223-7
- Series Print ISSN 2196-5501
- Series Online ISSN 2196-551X
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