Its Molecular Biology and Role in Human Health

  • Dolph L. Hatfield
  • Ulrich Schweizer
  • Petra A. Tsuji
  • Vadim N. Gladyshev

Table of contents

  1. Front Matter
    Pages i-xxxi
  2. The Machinery of Selenoprotein Biosynthesis

    1. Front Matter
      Pages 1-1
    2. Bradley A. Carlson, Byeong Jae Lee, Petra A. Tsuji, Ryuta Tobe, Jin Mo Park, Ulrich Schweizer et al.
      Pages 3-12
    3. Vadim N. Gladyshev, Bradley A. Carlson, Dolph L. Hatfield
      Pages 39-45
    4. Louise White, Sergi Castellano
      Pages 59-71
    5. Rebecca N. Dardashti, Linoy Dery, Reem Mousa, Shahar Dery, Post S. Reddy, Norman Metanis
      Pages 73-83
    6. Marco Mariotti, Didac Santesmasses, Roderic Guigó
      Pages 85-99
    7. Malgorzata Dobosz-Bartoszek, Miljan Simonović
      Pages 101-112
    8. Hisaaki Mihara, Ryuta Tobe, Nobuyoshi Esaki
      Pages 113-123
  3. Selenoproteins, Their Occurrence and Function

    1. Front Matter
      Pages 125-125
    2. Vadim N. Gladyshev
      Pages 127-139
    3. Catherine Méplan, John Hesketh
      Pages 151-173
    4. Jun Liu, Sharon Rozovsky
      Pages 187-198
    5. Edward E. Schmidt, Elias S. J. Arnér
      Pages 199-209
    6. Leopold Flohé, Regina Brigelius-Flohé
      Pages 211-222

About this book


In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involving selenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.


biosynthesis selenoprotein tRNA Selenocysteine ribosome profiling selenophosphate thioredoxin system T function inflammation

Editors and affiliations

  • Dolph L. Hatfield
    • 1
  • Ulrich Schweizer
    • 2
  • Petra A. Tsuji
    • 3
  • Vadim N. Gladyshev
    • 4
  1. 1.Mouse Cancer Genetics ProgramNational Institutes of Health, National Cancer InstituteBethesdaUSA
  2. 2.Institut für Biochemie und MolekularbiologieRheinische Friedrich-Wilhelms-Universität BonnBonnGermany
  3. 3.Department of Biological SciencesTowson UniversityTowsonUSA
  4. 4.Division of Genetics, Department of MedicineBrigham and Women’s Hospital Harvard Medical SchoolBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-41281-8
  • Online ISBN 978-3-319-41283-2
  • About this book