Authors:
Nominated as an outstanding Ph.D. thesis by the Lancaster University, UK
Presents a detailed study of amyloid-beta using multiple methods of atomic force microscopy
Author received the 2012 and 2014 Juno Award for Research Excellence from Lancaster University
Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (9 chapters)
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Front Matter
About this book
Amyloid-β (Aβ) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of Aβ with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes.
Keywords
- AFM Imaging of Amyloid-beta
- Nanomechanical Characterisation
- Alzheimer's Disease and AFM
- Aggregation of Amyloid-beta
- Ultrasonic Force Microscopy
Authors and Affiliations
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Research and Enterprise Services, Lancaster University , Lancaster, United Kingdom
Claire Louisa Tinker-Mill
Bibliographic Information
Book Title: Nanoscale Imaging and Characterisation of Amyloid-β
Authors: Claire Louisa Tinker-Mill
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-319-39534-0
Publisher: Springer Cham
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-39533-3Published: 12 July 2016
Softcover ISBN: 978-3-319-81907-5Published: 07 June 2018
eBook ISBN: 978-3-319-39534-0Published: 05 July 2016
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XX, 149
Number of Illustrations: 45 b/w illustrations, 14 illustrations in colour
Topics: Spectroscopy and Microscopy, Soft and Granular Matter, Complex Fluids and Microfluidics, Molecular Medicine, Neurology, Nanotechnology