From Pathogenesis to Comprehensive Management

  • John Varga
  • Christopher P. Denton
  • Fredrick M. Wigley
  • Yannick Allanore
  • Masataka Kuwana

Table of contents

  1. Front Matter
    Pages i-xxxv
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Christopher P. Denton, Marco Matucci-Cerinic
      Pages 3-7
  3. Epidemiology, Genetics and Classification

    1. Front Matter
      Pages 9-9
    2. Jammie K. Barnes, Luc Mouthon, Maureen D. Mayes
      Pages 11-24
    3. Shervin Assassi, Yannick Allanore
      Pages 25-38
    4. Robyn T. Domsic, Thomas A. Medsger Jr.
      Pages 39-48
    5. Sindhu R. Johnson, Lorinda Chung, Jaap Fransen, Frank H. J. Van den Hoogen
      Pages 49-64
    6. Pia Moinzadeh, Christopher P. Denton
      Pages 65-74
    7. Lauren V. Graham, Amy S. Paller, Ivan Foeldvari
      Pages 75-89
    8. Noelle M. Teske, Heidi T. Jacobe
      Pages 91-113
    9. Laura K. Hummers, Alan Tyndall
      Pages 115-123
    10. J. Matthew Mahoney, Jaclyn N. Taroni, Michael L. Whitfield
      Pages 125-129
  4. The Biological Basis of Systemic Sclerosis

    1. Front Matter
      Pages 131-131
    2. Lisa M. Rooper, Frederic B. Askin
      Pages 141-159
    3. Francesco Boin, Carlo Chizzolini
      Pages 161-195
    4. Kimberly Doering Maurer, Antony Rosen
      Pages 197-205
    5. Masataka Kuwana, Thomas A. Medsger Jr.
      Pages 207-220
    6. Mirko Manetti, Bashar Kahaleh
      Pages 221-244

About this book


Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.


autoimmune fibrosis pulmonary hypertension scleroderma systemic sclerosis

Editors and affiliations

  • John Varga
    • 1
  • Christopher P. Denton
    • 2
  • Fredrick M. Wigley
    • 3
  • Yannick Allanore
    • 4
  • Masataka Kuwana
    • 5
  1. 1.Feinberg School of MedicineNorthwestern UniversityChicagoUSA
  2. 2.Division of Medicine, Department of Inflammation, Centre for Rheumatology and Connective Tissue DiseasesUCL Division of Medicine, Royal Free HospitalLondonUnited Kingdom
  3. 3.Division of RheumatologyJohns Hopkins UniversityBaltimoreUSA
  4. 4.Service de Rhumatologie A, INSERMU1016Universit. Paris Descartes, Hôpital CochinParisFrance
  5. 5.Department of Allergy and RheumatologyNippon Medical School, Graduate School of MedicineTokyoJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-31405-1
  • Online ISBN 978-3-319-31407-5
  • About this book