Micro-, Meso- and Macro-Connectomics of the Brain

1. Front Matter

   Pages i-x

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2. Nanoconnectomics

   • Terrence J. Sejnowski

   Pages 1-10Open Access

3. Inhibitory Cell Types, Circuits and Receptive Fields in Mouse Visual Cortex

   • Edward M. Callaway

   Pages 11-18Open Access

4. Form Meets Function in the Brain: Observing the Activity and Structure of Specific Neural Connections

   • Karl Deisseroth

   Pages 19-29Open Access

5. The Network for Intracortical Communication in Mouse Visual Cortex

   • Andreas Burkhalter

   Pages 31-43Open Access

6. The Brain in Space

   • Kenneth Knoblauch, Mária Ercsey-Ravasz, Henry Kennedy, Zoltán Toroczkai

   Pages 45-74Open Access

7. In-Vivo Connectivity in Monkeys

   • Wim Vanduffel

   Pages 75-87Open Access

8. Parcellations and Connectivity Patterns in Human and Macaque Cerebral Cortex

   • David C. Van Essen, Chad Donahue, Donna L. Dierker, Matthew F. Glasser

   Pages 89-106Open Access

9. Connectome Networks: From Cells to Systems

   • Olaf Sporns

   Pages 107-127Open Access

10. Intra- and Inter-hemispheric Connectivity Supporting Hemispheric Specialization

    • Nathalie Tzourio-Mazoyer

    Pages 129-146Open Access

11. Genetics of the Connectome and the ENIGMA Project

    • Paul M. Thompson, Derrek P. Hibar, Jason L. Stein, Gautam Prasad, Neda Jahanshad

    Pages 147-164Open Access

12. Back Matter

    Pages 165-166

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This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.

• connectivity patterns
• nanoconnectomics
• intracortical communication
• connectome networks
• intra- and inter-hemispheric connectitivy

• Stem-Cell & Brain Res. Institute, Inserm U846, Bron, France

  Henry Kennedy

• Anatomy and Neurobiology Dept., Washington Univ. School of Medicine, St. Louis, USA

  David C. Van Essen

• Fondation Ipsen, Boulogne Billancourt, France

  Yves Christen