ABC Transporters - 40 Years on

  • Anthony M. George

Table of contents

  1. Front Matter
    Pages i-xiv
  2. ABC Transporters: A Structure-Function Perspective

    1. Front Matter
      Pages 1-1
    2. Lotteke J. Y. M. Swier, Dirk-Jan Slotboom, Bert Poolman
      Pages 3-36
    3. Seth W. Dickey, Som S. Chatterjee, Michael Otto
      Pages 53-64
    4. Markus A. Seeger, Enrica Bordignon, Michael Hohl
      Pages 65-84
  3. Human ABC Transporters of Medical Relevance

    1. Front Matter
      Pages 103-103
    2. King Leung Fung, Ryan C. Hunt, Chava Kimchi-Sarfaty, Michael M. Gottesman
      Pages 105-134
    3. Peter Chiba, Gerhard F. Ecker, Fauzia Nasim, Yaprak Dönmez-Cakil
      Pages 135-151
    4. Rituparna Mittra, Ellen M. Coyle, Richard Callaghan
      Pages 153-194
    5. Agnes Basseville, Matthew D. Hall, Cindy H. Chau, Robert W. Robey, Michael Gottesman, William D. Figg et al.
      Pages 195-226
    6. Yu Fukuda, John A. Lynch, John D. Schuetz
      Pages 273-296
    7. Robert C. Ford
      Pages 319-340

About this book

Introduction

This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders.

Keywords

ABC Transporter ATP binding cassette Allocrites Membrane proteins Substrate transporter

Editors and affiliations

  • Anthony M. George
    • 1
  1. 1.School of Life SciencesUniversity of TechnologySydneyAustralia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-23476-2
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-23475-5
  • Online ISBN 978-3-319-23476-2
  • About this book