Medullary Thyroid Carcinoma

Biology – Management – Treatment

  • Friedhelm Raue

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 204)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Gilbert J. Cote, Elizabeth G. Grubbs, Marie-Claude Hofmann
    Pages 1-39
  3. Friedhelm Raue, Karin Frank-Raue
    Pages 61-90
  4. Stefan Delorme, Friedhelm Raue
    Pages 91-116
  5. Yoon Ju Bae, Michael Schaab, Juergen Kratzsch
    Pages 117-137
  6. Karin Frank-Raue, Friedhelm Raue
    Pages 139-156
  7. Venessa H. M. Tsang, Lyndal J. Tacon, Diana L. Learoyd, Bruce G. Robinson
    Pages 157-178
  8. Maria Alevizaki, Katerina Saltiki
    Pages 179-186
  9. Andreas Machens, Henning Dralle
    Pages 187-205
  10. Friedhelm Raue, Karin Frank-Raue
    Pages 207-225
  11. Ramona Dadu, Mimi N. Hu, Elizabeth G. Grubbs, Robert F. Gagel
    Pages 227-249

About this book

Introduction

​This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disease is described, and the significance of other tumor markers is also considered. With regard to treatment, the use of thyroidectomy is fully discussed, including in children carrying the mutations in the RET proto-oncogene considered causative for MEN 2. Additionally, the value of tyrosine kinase inhibitors as the most effective treatment modality in patients with a large tumor burden or rapid tumor growth, or both, is explained. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.

Keywords

Calcitonin Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia Type 2 Pheochromocytoma RET protooncogene

Editors and affiliations

  • Friedhelm Raue
    • 1
  1. 1.Endocrine Practice and Molecular Laboratory, Medical FacultyUniversity of Heidelberg HeidelbergGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-22542-5
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-22541-8
  • Online ISBN 978-3-319-22542-5
  • Series Print ISSN 0080-0015
  • Series Online ISSN 2197-6767
  • About this book