Brain Function and Responsiveness in Disorders of Consciousness

1. Front Matter

   Pages i-xi

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2. Responsiveness in DoC: A Quest for Consciousness?

   • Walter G. Sannita

   Pages 1-11

3. Advances in the Scientific Investigation of Consciousness

   • Daniel Bor

   Pages 13-24

4. Behavioral Responsiveness in Patients with Disorders of Consciousness

   • Lizette Heine, Steven Laureys, Caroline Schnakers

   Pages 25-36

5. Clinical Evaluation of Residual Brain Function and Responsiveness in Disorders of Consciousness

   • Heinrich Binder

   Pages 37-49

6. Measuring Consciousness Through Imaging

   • Carol Di Perri, Jitka Annen, Georgios Antonopoulos, Enrico Amico, Carlo Cavaliere, Steven Laureys

   Pages 51-65

7. Decoding Thoughts in Disorders of Consciousness

   • Adrian M. Owen, Lorina Naci

   Pages 67-80

8. Brain Responsiveness After Severe Brain Injury: Revolutions and Controversies

   • Evan S. Lutkenhoff, Martin M. Monti

   Pages 81-92

9. Exploring the Neurophysiological Correlates of Loss and Recovery of Consciousness: Perturbational Complexity

   • Silvia Casarotto, Mario Rosanova, Olivia Gosseries, Mélanie Boly, Marcello Massimini, Simone Sarasso

   Pages 93-104

10. Brain Electrophysiology in Disorders of Consciousness: Diagnostic and Prognostic Utility

    • Damian Cruse, G. Bryan Young, Francesco Piccione, Marianna Cavinato, Aldo Ragazzoni

    Pages 105-118

11. The Persistent Vegetative State: Evidence That the Lower Brain Survives Because Its Neurons Intrinsically Resist Ischemia

    • R. David Andrew

    Pages 119-144

12. Responsiveness and the Autonomic Control–CNS Two-Way Interaction in Disorders of Consciousness

    • Francesco Riganello

    Pages 145-155

13. The Medical Practice Impact of Functional Neuroimaging Studies in Patients with Disorders of Consciousness

    • James L. Bernat

    Pages 157-169

14. Vegetative State Two Decades After the Multi-Society Task Force (MSTF) Report

    • Gastone G. Celesia

    Pages 171-184

15. Moving Beyond End of Life: The Ethics of Disorders of Consciousness in an Age of Discovery and Uncertainty

    • L. Syd M. Johnson

    Pages 185-194

16. Mesocircuit Mechanisms Underlying Recovery of Consciousness Following Severe Brain Injuries: Model and Predictions

    • Nicholas D. Schiff

    Pages 195-204

17. Back Matter

    Pages 205-207

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This book provides up-to-date information on all aspects of brain function and responsiveness in patients with severe disorders of consciousness. Topics considered include the mechanisms and measures of consciousness; perfusional, metabolic, and fMRI markers of responsiveness; responsiveness to pain; the role of brain–computer interface techniques; electrophysiology; cortical excitability; autonomic responsiveness; the natural history of vegetative and minimally conscious states; and prediction of outcome. Brain neuroimaging has documented residual responsiveness in the vegetative state. The scientific impact of this seminal evidence has generated a schism between neuroscience and the clinical criteria defining consciousness and responsiveness. Our current understanding of human consciousness must be reconsidered also in view of the emotional impact on the public and the far-reaching implications for diagnosis, prognosis, medical treatment, human costs, medical and individual responsibility, logistics, healthcare, ethics, etc. It is hoped that this book will help to bridge the gap between neuroscience and clinical routine.

• Brain injury
• Neuroimaging
• Neurorehabilitation
• Pain responsiveness
• Perfusion
• Vegetative state

• Dept. of Psychology and Neurosurgery, University of California, L.A., Los Angeles, USA

  Martin M. Monti

• Dept of Neurosc, Ophthalmol and Genetics, University of Genova, Genova, Italy

  Walter G. Sannita

Responsiveness in Doc: A Quest for Consciousness?.- Advances in the Scientific Investigation of Consciousness.- Behavioral Responsiveness in Patients with Doc.- Clinical Evaluation of Residual Brain Function and Responsiveness in Disorders of Consciousness.- Measuring Consciousness through Imaging.- Decoding Thoughts in Disorders of Consciousness.- Brain Responsiveness after Severe Brain Injury: Revolutions and Controversies.- Exploring the Neurophysiological Correlates of Loss and Recovery Of Consciousness: Perturbational Complexity.- Brain Electrophysiology in Disorders of Consciousness: Diagnostic and Prognostic Utility.- The Persistent Vegetative State: Evidence That the Lower Brain Survives Because its Neurons Intrinsically Resist Ischemia.- Responsiveness and the Autonomic Control – CNS Two-Way Interaction in Disorders of Consciousness.- The Medical Practice Impact of Functional Neuroimaging Studies in Patients with Disorders of Consciousness.- Vegetative State Two Decades After The Multi-Society Task Force (MSTF) Report.- Moving Beyond End-Of-Life: The Ethics of Disorders of Consciousness in an Age of Discovery and Uncertainty.