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  • © 2015

Excipient Applications in Formulation Design and Drug Delivery

  • Provides an in-depth perspective into a spectrum of excipient focused topics highly relevant to drug development and manufacture

  • Examines how the functional attributes of excipients affect biological systems and drug absorption and delivery

  • Discusses the role of excipients in the drug approval process

  • Includes supplementary material: sn.pub/extras

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xl
  2. Excipient Applications in Formulation Design and Drug Delivery

    • Ajit S. Narang, Sai HS. Boddu
    Pages 1-10
  3. Drug-Excipient Interactions and Their Stability Implications

    1. Front Matter

      Pages 11-11
    2. Drug Excipient Interactions

      • Ajit S. Narang, Aaron Yamniuk, Limin Zhang, S. Nilgun Comezoglu, Dilbir S. Bindra, Sailesh A. Varia et al.
      Pages 13-35
    3. Reactive Impurities in Excipients

      • Yongmei Wu, Jaquan K. Levons, Ajit S. Narang, Krishnaswamy Raghavan, Rao V. Mantri
      Pages 37-65
    4. Reactive Impurities in PEG: A Case Study

      • Jeffrey N. Hemenway, Thiago C. Carvalho, Rao V. Mantri, Yongmei Wu, Jaquan K. Levons, Ajit S. Narang et al.
      Pages 67-91
    5. Impact of Excipient Interactions on Solid Dosage Form Stability

      • Ajit S. Narang, Divyakant Desai, Sherif Badawy
      Pages 93-137
    6. Protein—Surfactant Interactions at the Air-Water Interface

      • Alfredo R. Narváez, Shyam V. Vaidya
      Pages 139-166
  4. Impact of Excipients on Drug Release and Bioavailability

    1. Front Matter

      Pages 167-167
    2. Smart Polymers in Drug Delivery

      • Sushant Lakkadwala, Sanko Nguyen, Jerry Nesamony, Ajit S. Narang, Sai HS. Boddu
      Pages 169-199
    3. Tailoring the Release of Drugs Using Excipients

      • Chandrasekhar Garapati, Himanshu Gupta, Jwala Renukuntla, Sai HS. Boddu
      Pages 201-236
    4. Solid Lipid Excipients as Matrix Agents for Sustained Drug Delivery

      • Yvonne Rosiaux, Vincent Jannin, Sophie Hughes, Delphine Marchaud
      Pages 237-271
    5. Biopolymers in Medical Implants

      • Rachana Bhatt, Michael Jaffe
      Pages 311-348
  5. Excipients Selection and Formulation Design

    1. Front Matter

      Pages 349-349
    2. Selection of Excipients Based on the Biopharmaceutics Classification System of Drugs

      • Gabriella Baki, Sachin Chaudhari, Ripal Gaudana, Sai HS. Boddu
      Pages 351-383
    3. Excipient Selection in Oral Solid Dosage Formulations Containing Moisture Sensitive Drugs

      • Ali R. Rajabi-Siahboomi, Marina Levina, Sampada B. Upadhye, Jason Teckoe
      Pages 385-421
    4. Silicone Excipients in Pharmaceutical Drug Delivery Applications

      • Gerald K. Schalau, Hyder A. Aliyar
      Pages 423-462
    5. Excipients That Facilitate Amorphous Drug Stabilization

      • Yangjie Wei, Bhaswati Dattachowdhury, Kiran K. Vangara, Niraja Patel, Kenneth Alexander, Sai HS. Boddu
      Pages 463-495
    6. Excipients in Pediatric Formulations: Biopharmaceutical and Toxicological Considerations

      • Kiran K. Vangara, Venkata Kashyap Yellepeddi
      Pages 497-519

About this book

In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.

Keywords

  • amorphous drugs
  • drug delivery
  • excipients
  • generics
  • impurities

Editors and Affiliations

  • Bristol-Myers Squibb, Co., New Brunswick, USA

    Ajit S Narang

  • Division of Industrial Pharmacy, Department of Pharmacy Practice, The University of Toledo, TOLEDO, USA

    Sai H S. Boddu

About the editors

Ajit Narang earned his Ph.D. from the University of Tennessee in Memphis, his Masters in Pharmaceutics from the Banaras Hindu University in India, and his Bachelors in Pharmaceutical sciences from the University of Delhi in India. He has over 13 years of pharmaceutical industry experience and is currently a Principal Scientist for the Drug Product Science & Technology Department of Bristol-Myers Squibb, Co. (BMS) in New Brunswick, NJ. He also serves as Adjunct Faculty at the Universities of Tennessee and Phoenix, Industrial Advisory Board member of Western Michigan University, Editor of Bentham Pharmaceutical Journal, and as a panel member of the Biopharmaceutics Technical Committee (BTC) of the Pharmaceutical Quality Research Institute (PQRI) in Arlington, VA. Ajit is also a long standing AAPS member and has served the AAPS in many different capacities. He has published over 40 peer reviewed articles, 2 books, 7 patent applications, 20 invited talks, and 60 presentations at various scientific meetings.

Sai HS. Boddu, Ph.D, is an Assistant Professor of Pharmaceutics at The University of Toledo (UT). Prior to joining UT, he received his Ph.D. in Pharmaceutical Sciences from The University of Missouri-Kansas City (UMKC). His research areas include Drug Delivery, Bioanalysis and Pharmacokinetics. He was the recipient of the prestigious UMKC-Chancellor’s Doctoral Fellowship Award for the years 2008-2010. He has been named as Vice Chancellor for Student Affairs and En

rollment Management Honor Recipient for the Fall of 2010. With more than twelve years of experience in drug delivery, he has authored and co-authored many scientific papers, book chapters and patents in the areas of pre-formulation, formulation development, nanotechnology and bioanalysis. He served as a Steering Committee member of the AAPS Excipient Focus Group from 2010-2012.

Bibliographic Information

  • Book Title: Excipient Applications in Formulation Design and Drug Delivery

  • Editors: Ajit S Narang, Sai H S. Boddu

  • DOI: https://doi.org/10.1007/978-3-319-20206-8

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-20205-1Published: 30 September 2015

  • Softcover ISBN: 978-3-319-37107-8Published: 29 October 2016

  • eBook ISBN: 978-3-319-20206-8Published: 07 October 2015

  • Edition Number: 1

  • Number of Pages: XL, 681

  • Number of Illustrations: 86 b/w illustrations, 75 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access