Editors:
- This is the first book that provides up-to-date, comprehensive reviews on the monooxygenase, peroxidase and peroxygenase properties and mechanisms of cytochrome P450 enzymes in 13 chapters compiled by leading scientists in their field
- This book is available in paper and electronic formats and will be helpful to researchers and graduate students in their areas
- Customers should purchase this book as there are no recent books on the market that review the peroxidase and peroxygenase properties of cytochrome P450 enzymes
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 851)
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Table of contents (13 chapters)
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Front Matter
About this book
This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.
Editors and Affiliations
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Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada
Eugene G. Hrycay
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Fac. of Pharmaceutical Sciences, The University of British Columbia , Vancouver, Canada
Stelvio M. Bandiera
Bibliographic Information
Book Title: Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450
Editors: Eugene G. Hrycay, Stelvio M. Bandiera
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-16009-2
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015
Hardcover ISBN: 978-3-319-16008-5Published: 09 June 2015
Softcover ISBN: 978-3-319-34794-3Published: 12 October 2016
eBook ISBN: 978-3-319-16009-2Published: 22 May 2015
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XV, 368
Number of Illustrations: 91 b/w illustrations, 59 illustrations in colour
Topics: Biomedicine general