© 2015

The Mechanobiology of Obesity and Related Diseases

  • Amit Gefen
  • Dafna Benayahu

Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 16)

Table of contents

  1. Front Matter
    Pages i-x
  2. Cees Oomens, Gerrit Peters
    Pages 3-9
  3. Junghyo Jo, Zeina Shreif, Jonathan R. Gaillard, Matilde Arroyo, Samuel W. Cushman, Vipul Periwal
    Pages 11-34
  4. Yoshiyuki Tanabe, Maki Tanji Saito, Koichi Nakayama
    Pages 35-62
  5. Naama Shoham, Natan T. Shaked, Dafna Benayahu, Amit Gefen
    Pages 89-103
  6. Tarja Lyytinen, Timo Bragge, Tuomas Liikavainio, Paavo Vartiainen, Pasi A. Karjalainen, Jari P. Arokoski
    Pages 125-147
  7. Julie R. Steele, Diane L. Riddiford-Harland, Karen J. Mickle
    Pages 149-179
  8. Yao Fu, Timothy M. Griffin
    Pages 181-201
  9. Sewon Lee, Srijita Dhar, Kwangseok Hong, Yan Yang, Michael A. Hill
    Pages 233-270
  10. Tao Zhang, Mikhail G. Kolonin
    Pages 271-294
  11. Back Matter
    Pages 295-296

About this book


This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases.
There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.


Cell Damage Cell Deformation Cell Growth Cell-matrix Mechanical Interactions Cellular Mechanics Cytoskeleton Extracellular Matrix Focal Adhesion Lipids Mechanically-activated Signaling Pathways Obesity Disease Mechanisms

Editors and affiliations

  • Amit Gefen
    • 1
  • Dafna Benayahu
    • 2
  1. 1.Department of Biomedical EngineeringTel Aviv University Faculty of EngineeringTel AvivIsrael
  2. 2.Dept. of Cell and Developmental Biology Faculty of MedicineTel Aviv UniversityRamat AvivIsrael

Bibliographic information