An up-to-date comprehensive overview of ADAMTS-13 basic science, including less-recognized aspects of the protein
Covers ADAMTS-13's role in disease, including its potential as a therapeutic agent
One of the only books to focus on this specific protein, it fills a gap in the literature and its coverage of both scientific and clinical aspects make it relevant both to researchers and clinicians
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Table of contents (9 chapters)
About this book
This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility.
Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.
- Von Willebrand
“The purpose is to provide a current overview of ADAMTS13, spanning basic science and clinical medicine. … of interest to any medical students, residents, practicing physicians, or allied health practitioners involved in the care of these patients. … If you are even remotely interested in ADAMTS13, you must get this book. This is most certainly one of the best current reviews of this subject available today.” (Valerie L. Ng, Doody’s Book Reviews, November, 2015)
Editors and Affiliations
Division of Hematology, University of Utah Health Sciences Center, Salt Lake City, USA
George M. Rodgers
About the editor
Dr. George M. Rodgers received his M.D. and Ph.D. in Pharmacology from Tulane University Medical School in New Orleans, Louisiana. He completed his internal medicine training at Baylor College of Medicine in Houston, Texas, along with a hematology fellowship at the University of California, San Francisco, and served on the UCSF faculty. He is currently Professor of Medicine and Pathology at the University of Utah Medical Center in Salt Lake City and Medical Director of the Coagulation Laboratory at ARUP Laboratories. Dr. Rodgers is board certified in internal medicine, hematology and hematopathology. His clinical interests are in benign hematology, particularly coagulation disorders, and his basic research interests are in vascular biology, especially endothelial cell regulation of hemostasis. A current project is studying the role of ADAMTS13 in angiogenesis.
Book Title: ADAMTS13
Book Subtitle: Biology and Disease
Editors: George M. Rodgers
Publisher: Springer Cham
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-08716-0Published: 15 September 2015
Softcover ISBN: 978-3-319-34730-1Published: 29 October 2016
eBook ISBN: 978-3-319-08717-7Published: 13 August 2015
Edition Number: 1
Number of Pages: X, 186
Number of Illustrations: 9 b/w illustrations, 24 illustrations in colour