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  • © 2015

Biopsy Diagnosis of Peripheral Neuropathy

  • Practical guidance on differential diagnosis based on pathology and clinical presentation

  • Advice on selection of ancillary techniques (molecular, immunohistochemical and genetic) to establish a definitive diagnosis

  • Numerous high-quality color photomicrographs and electron micrographs illustrating the wide variety of pathologic findings

Buying options

eBook USD 119.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-07311-8
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 159.99
Price excludes VAT (USA)
Hardcover Book USD 219.99
Price excludes VAT (USA)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xxi
  2. Peripheral Neuropathy and the Role of Nerve Biopsy

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 1-20
  3. Normal Anatomy of the Peripheral (Sural) Nerve

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 21-41
  4. Quantitative Techniques

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 43-50
  5. The Axon: Normal Structure and Pathological Alterations

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 51-84
  6. Schwann Cells and Myelin in the Peripheral Nervous System

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 85-109
  7. The Peripheral Nerve Vasculature

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 111-122
  8. Examination of the Peripheral Nerve Biopsy

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 123-149
  9. Clinical Aspects of Peripheral Neuropathy

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 151-159
  10. The Inflammatory Demyelinating Neuropathies

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 161-196
  11. Idiopathic Inflammatory Neuropathies

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 197-207
  12. Infectious Diseases Causing Neuropathy

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 209-224
  13. Leprous Neuropathy

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 225-243
  14. Vasculitic Neuropathy

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 245-271
  15. Dysproteinemic Neuropathies

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 273-293
  16. Amyloid Neuropathy

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 295-309
  17. Neuropathy Associated with Neoplasia

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 311-330
  18. Neuropathy Associated with Endocrine and Metabolic Disease

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 331-354
  19. Toxic Neuropathies

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 355-374
  20. Genetically Determined Neuropathies

    • Juan M. Bilbao, Robert E. Schmidt
    Pages 375-428

About this book

Peripheral nerve analysis is a challenging task for pathologists, given the advent of new diagnoses and techniques of analysis and the impact of molecular genetics. This book presents a simple, logical method for constructing a differential diagnosis based on pathology and clinical presentation. It also provides advice on the selection of ancillary molecular, immunohistochemical and genetic techniques to establish a definitive diagnosis. Clear, authoritative guidance is offered on diagnosis of the full range of neuropathies with the aid of a wealth of high-quality color photomicrographs and electron micrographs. The pathologist will benefit greatly from the identification of a variety of artifacts and normal structures occasionally encountered in nerve biopsies that need to be distinguished from specific pathologic alterations. This user-friendly, practical text will be an invaluable aid in achieving the most specific diagnosis possible.

Keywords

  • Autonomic Pathology
  • Axonopathy
  • Demyelination
  • Painful Neuropathy
  • Toxins

Reviews

From the book reviews:

“This book presents a simple, logical method for constructing a differential diagnosis of peripheral nerve disease based on pathology and clinical presentation. … The intended audience is pathologists, neurologists, and neuroscientists in training, but the book is also appropriate for pathology residents and neuropathology fellows, as well as neuroscientists. … This user-friendly, practical book will be an invaluable aid in achieving the most specific diagnosis possible.” (Arlette Habashi, Doody’s Book Reviews, April, 2015)

Authors and Affiliations

  • Professor Emeritus of Neuropathology, Sunnybrook and St Michael’s Hospitals, University of Toronto, Toronto, Canada

    Juan M Bilbao

  • Professor of Pathology and Immunology, Director, Division of Neuropathology, Department of Pathology, Washington University School of Medicine, St. Louis, USA

    Robert E Schmidt

About the authors

Robert E. Schmidt, MD, PhD, graduated from Washington University School of Medicine and has since spent his entire career at the School. For the past two decades he has been Director of the Division of Neuropathology and Professor of Pathology and in 2006 he was also appointed Director of the Research Electron Microscopy Core Laboratory. Dr. Schmidt is the recipient of various honors and awards and is a member of the Alpha Omega Alpha Honor Medical Society. He is a longstanding member of the editorial board of the Journal of Neuropathology and Experimental Neurology and since 2007 has been Senior Editor of Brain Pathology. Dr. Schmidt is the lead or co-author of 140 articles in peer-reviewed journals, as well as many reviews and other publications. Juan M. Bilbao, MD, graduated from Universidad Nacional de la Plata, Argentina and then undertook residencies in Boston and Montreal. He received his certification in Neuropathology from the American Board of Pathology in 1972 and the Royal College of Physicians and Surgeons of Canada in 1973. Dr. Bilbao has been an Associate Professor in Laboratory Medicine and Pathobiology at the University of Toronto since 1997 and Consultant Neuropathologist at the Toronto Hospital Corporation since 1998. He is also now Associate Pathologist (Neuropathology) at St. Michael’s Hospital, Toronto. Dr. Bilbo is a past Chief Examiner, Section of Neuropathology, for the Royal College of Physicians and Surgeons of Canada. He is the author of 124 articles in peer-reviewed journals and numerous other publications.

Bibliographic Information

  • Book Title: Biopsy Diagnosis of Peripheral Neuropathy

  • Authors: Juan M Bilbao, Robert E Schmidt

  • DOI: https://doi.org/10.1007/978-3-319-07311-8

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-07310-1

  • Softcover ISBN: 978-3-319-37659-2

  • eBook ISBN: 978-3-319-07311-8

  • Edition Number: 2

  • Number of Pages: XXI, 486

  • Number of Illustrations: 81 b/w illustrations, 221 illustrations in colour

  • Topics: Pathology, Neurology, Neurosurgery, Neuroscience

Buying options

eBook USD 119.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-07311-8
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 159.99
Price excludes VAT (USA)
Hardcover Book USD 219.99
Price excludes VAT (USA)