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© 2013

Structural and Functional Characterization of the Immunoproteasome

Book

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Eva Maria Huber
    Pages 1-18
  3. Eva Maria Huber
    Pages 19-19
  4. Eva Maria Huber
    Pages 21-39
  5. Eva Maria Huber
    Pages 41-70
  6. Eva Maria Huber
    Pages 71-76
  7. Back Matter
    Pages 77-82

About this book

Introduction

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

Keywords

Antigen Generation Drugs for Cancers and Autoimmune Diseases Immunoproteasome X-ray Structure Proteasome Inhibition Protein Crystallography Proteolytic Degradation Structure-based Drug Design Ubiquitin-proteasome System

Authors and affiliations

  1. 1.Chair of BiochemistryTechnische Universität MünchenGarchingGermany

About the authors

Eva Huber studied biochemistry at the Technische Universität München (TUM) from 2004 till 2009. For her master studies, which were funded by the Studienstiftung des deutschen Volkes, she received the Jürgen-Manchot Studienpreis from the faculty of chemistry of the TUM. During her postgraduate studies (2009-2013) in the group of Prof. Groll at the TUM she succeeded in the elucidation of the mouse immuno- and constitutive proteasome X-ray structures in their unliganded state and in complex with the immunoproteasome-selective compound ONX 0914. For these results she has been awarded the “Management Engineers Presidential Award” in 2012.

Bibliographic information