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Ibuprofen: Pharmacology, Therapeutics and Side Effects

  • K. D.┬áRainsford

Table of contents

  1. Front Matter
    Pages i-xx
  2. K. D. Rainsford
    Pages 1-4
  3. K. D. Rainsford
    Pages 5-42
  4. K. D. Rainsford
    Pages 59-76
  5. K. D. Rainsford
    Pages 77-90
  6. K. D. Rainsford
    Pages 91-122
  7. K. D. Rainsford
    Pages 123-139
  8. K. D. Rainsford
    Pages 141-162
  9. K. D. Rainsford
    Pages 163-164
  10. K. D. Rainsford
    Pages 165-168
  11. K. D. Rainsford
    Pages 169-173
  12. K. D. Rainsford
    Pages 183-188
  13. K. D. Rainsford
    Pages 189-190
  14. Back Matter
    Pages 191-243

About this book

Introduction

Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs.

This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.

Keywords

Analgesic drugs Anti-inflammatory drugs Gastro-intestinal toxicity Hepatic toxicity Non-steroidal anti-inflammatory drugs Renal toxicity

Authors and affiliations

  • K. D.┬áRainsford
    • 1
  1. 1.Biomedical Res. CentreSheffield Hallam UniversitySheffieldUnited Kingdom

Bibliographic information