Galanin

  • Tomas Hökfelt

Part of the Experientia Supplementum book series (EXS, volume 102)

Table of contents

  1. Front Matter
    Pages i-x
  2. T. Hökfelt, K. Tatemoto
    Pages 1-5
  3. K. Mitsukawa, X. Lu, T. Bartfai
    Pages 7-23
  4. S-A. Hobson, A. Bacon, C. R. Elliot-Hunt, F. E. Holmes, N. C. H. Kerr, R. Pope et al.
    Pages 25-38
  5. Xiao-Jun Xu, Tomas Hökfelt, Zsuzsanna Wiesenfeld-Hallin
    Pages 39-50
  6. J. W. Bauer, R. Lang, M. Jakab, B. Kofler
    Pages 51-59
  7. Helmut Butzkueven, Andrew L. Gundlach
    Pages 61-69
  8. Istvan Merchenthaler
    Pages 71-85
  9. Jessica R. Barson, Irene Morganstern, Sarah F. Leibowitz
    Pages 87-111
  10. Zaida Díaz-Cabiale, Concepción Parrado, Manuel Narváez, Carmelo Millón, Araceli Puigcerver, Kjell Fuxe et al.
    Pages 113-131
  11. Scott E. Counts, Sylvia E. Perez, Stephen D. Ginsberg, Elliott J. Mufson
    Pages 143-162
  12. Eugenia Kuteeva, Tomas Hökfelt, Tara Wardi, Sven Ove Ögren
    Pages 163-181
  13. J. T. Lerner, R. Sankar, A. M. Mazarati
    Pages 183-194
  14. Marina R. Picciotto
    Pages 195-208
  15. I. Rauch, Barbara Kofler
    Pages 223-241
  16. Elsie Tachie Mensah, Helene Volkoff, Suraj Unniappan
    Pages 243-262
  17. Catherine B. Lawrence, Gregory S. Fraley
    Pages 263-280
  18. Back Matter
    Pages 281-285

About this book

Introduction

Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.

Keywords

Alzheimer's disease CNS alcohol behavior biological energy homeostasis molecule nervous system pain plasticity receptor receptors skin system

Editors and affiliations

  • Tomas Hökfelt
    • 1
  1. 1.Dept. NeuroscienceKarolinska InstituteStockholmSweden

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-0346-0228-0
  • Copyright Information Springer Basel AG 2010
  • Publisher Name Springer, Basel
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-0346-0227-3
  • Online ISBN 978-3-0346-0228-0
  • Series Print ISSN 1023-294X
  • About this book