GABA and Sleep

Molecular, Functional and Clinical Aspects

  • Jaime M. Monti
  • Seithikurippu Ratnas Pandi-Perumal
  • Hanns Möhler

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Basic Physiology and Pharmacology

  3. Sleep Science and Circuitry

    1. Front Matter
      Pages 119-119
    2. Fernando Reinoso-Suárez, Carmen de la Roza, Margarita L Rodrigo-Angulo, Isabel de Andrés, Ángel Núñez, Miguel Garzón
      Pages 233-252
    3. Daniel P. Cardinali, S. R. Pandi-Perumal, Lennard P. Niles, Gregory M. Brown
      Pages 279-301
    4. J. Christopher Ehlen, Daniel L. Hummer, Ketema N. Paul, H. Elliott Albers
      Pages 303-321
  4. Hypnotics

    1. Front Matter
      Pages 323-323
    2. Thomas C. Wetter, Pierre A. Beitinger, Marie E. Beitinger, Bastian Wollweber
      Pages 325-361
    3. Luc Staner, Françoise Cornette, Sarah Otmani, Jean -François Nedelec, Philippe Danjou
      Pages 383-411
    4. David N. Neubauer
      Pages 453-464
  5. Back Matter
    Pages 481-486

About this book


GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. This book brings together many of the world’s leading investigators to discuss current and anticipated developments in the areas of geriatric sleep medicine and provides a comprehensive examination of current principles and practice in this field. It is divided into three main sections: Section I: Basic Physiology and Pharmacology Section II: Sleep Science and Circuitry Section III: Neurotherapeutics The areas covered include findings from research investigations various aspects of GABAergic systems and the regulation of sleep. The book is suitable for basic and clinical neuropharmacologists, sleep researchers, psychiatrists, sleep disorders specialists, clinicians, medical students, and all professionals interested in the interdisciplinary areas of sleep and neuropharmacology.


Insomnia pathophysiology physiology regulation

Editors and affiliations

  • Jaime M. Monti
    • 1
  • Seithikurippu Ratnas Pandi-Perumal
    • 2
  • Hanns Möhler
    • 3
  1. 1.School of Medicine, Dept. Pharmacology & TherapeuticsClinics Hospital MontevideoMontevideoUruguay
  2. 2.Somnogen, Inc.TorontoCanada
  3. 3.Institut für Pharmakologie und, ToxikologieUniversität ZürichZürichSwitzerland

Bibliographic information