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Gene Therapy for Autoimmune and Inflammatory Diseases

  • Yuti Chernajovsky
  • Paul D. Robbins

Part of the Milestones in Drug Therapy book series (MDT)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Florence Apparailly, Paul Peter Tak, Christian Jorgensen
    Pages 1-18
  3. Melanie A. Ruffner, Scott E. Plevy, Anthony T. Cheung
    Pages 19-37
  4. Hirofumi Noguchi
    Pages 39-46
  5. Stephanie G. Sumner-Jones, Deborah R. Gill, Stephen C. Hyde
    Pages 47-64
  6. Roberto Furlan, Chiara Maiorino, Alberto Gatta, Francesca Ruffini, Gianvito Martino
    Pages 65-78
  7. Hans H. Jung, Juliane Bremer, Michael Weller
    Pages 79-90
  8. Steven C. Ghivizzani, Christopher H. Evans
    Pages 91-112
  9. Nienke Roescher, Paul Peter Tak, John A. Chiorini
    Pages 113-125
  10. Rizgar A. Mageed, Taher E. Taher, Ali S. Jawad
    Pages 127-146
  11. Jeroen Geurts, Wim B. van den Berg, Fons A. J. van de Loo
    Pages 147-159
  12. Chengwen Li, Matthew L. Hirsch, R. Jude Samulski
    Pages 161-180
  13. Maria C. Subang, David J. Gould
    Pages 181-192
  14. Nicola Brunetti-Pierri, Philip Ng
    Pages 193-207
  15. Ingo H. Tarner
    Pages 209-222
  16. Back Matter
    Pages 233-244

About this book

Introduction

In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.

Keywords

Arthritis Autoimmune Diseases DNA Immunology Inflammatory Diseases Promoter gene therapy genes

Editors and affiliations

  • Yuti Chernajovsky
    • 1
  • Paul D. Robbins
    • 2
  1. 1.Bone and Joint Research Unit Barts and The London School of MedicineQueen Mary University of LondonLondonUK
  2. 2.Department of Microbiology and Molecular GeneticsUniversity of Pittsburgh School of MedicinePittsburghUSA

Bibliographic information