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Lassa Fever: Epidemiology, Immunology, Diagnostics, and Therapeutics

  • Book
  • © 2023

Overview

Editors:
  1. Robert Garry

    1. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, USA

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  • Provides detailed information on genetics, function and epidemiology of LASV
  • Reviews key findings from 50 years of Lassa fever research
  • Explores latest diagnostic strategies as well as antibody therapy and vaccines

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 440)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. 50 Years of Lassa Fever Research

    • Robert F. Garry
    Pages 1-22

  3. Lassa Virus Genetics

    • Raphaëlle Klitting, Samar B. Mehta, Judith U. Oguzie, Paul E. Oluniyi, Matthias G. Pauthner, Katherine J. Siddle et al.
    Pages 23-65

  4. Ecology of Lassa Virus

    • Allison R. Smither, Antoinette R. Bell-Kareem
    Pages 67-86

  5. Epidemiology of Lassa Fever

    • Antoinette R. Bell-Kareem, Allison R. Smither
    Pages 87-109

  6. Lassa Virus Countermeasures

    • Lilia I. Melnik
    Pages 111-145

  7. Lassa Virus Structural Biology and Replication

    • Robert F. Garry
    Pages 147-164

  8. Lassa Fever Natural History and Clinical Management

    • Donald S. Grant, Robert J. Samuels, Robert F. Garry, John S. Schieffelin
    Pages 165-192
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Keywords

About this book

This volume provides a comprehensive and up-to-date overview of the various aspects of Lassa virus (LASV), the causative agent of Lassa fever, a frequently fatal zoonotic disease endemic to West Africa. Compiled by world-leading experts in the field, this book provides an introduction to the 50-year history of Lassa fever research, the genetic diversity of LASV, and its geographic distribution. Subsequent chapters focus on the ecology and epidemiology of LASV, discussing in-depth the interactions of the virus with its hosts - multimammate mice and other rodents - and the interactions between these animal reservoirs and humans. The book also details the many advances in understanding the structural biology and replication of LASV, including new insights into the structure and function of its proteins. These advances in the basic understanding of LASV biology have enabled the development of LASV countermeasures, including sensitive and specific diagnostic assays. Promising drugcandidates, including monoclonal antibodies, and vaccines are also discussed. A final and essential chapter addresses current and future clinical practice for clinical management of Lassa fever. 
This volume is intended for researchers and clinicians in the fields of virology, epidemiology, and microbiology.

Editors and Affiliations

  • Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, USA

    Robert Garry

About the editor

Dr. Robert F. Garry is the manager of a partnership of scientists striving to deepen understanding of emerging pathogens such as Lassa virus. His efforts have led to the production of Lassa fever diagnostics and development of improved research and clinical infrastructure in West Africa. Here, he draws on those experiences to summarize essential knowledge about Lassa virus and to foreshadow important advances that are coming to control and treat of this important human pathogen. 

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