Overview
- Addresses the multifaceted interactions of the nervous system with cancer and tumor microenvironment
- Describes new in vivo and in vitro model system used in cancer neurobiology research
- Demonstrates the role of the nervous system as a novel actionable target in oncology
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Table of contents (13 chapters)
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Front Matter
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Cancer and the Peripheral Nervous System
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Front Matter
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Perspectives of the Field
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Front Matter
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Back Matter
Keywords
About this book
This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies.
This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.Editors and Affiliations
About the editors
Dr. Amit is dedicated to key areas of cancer research that will develop therapeutic approaches to improve patients’ survival, treatment responses, and quality of life. During his residency training, Dr. Amit became interested in the biology of cancer. After completing his residency, he undertook further training in Head and Neck Surgical Oncology at The University of Texas MD Anderson Cancer Center, where he completed a clinical fellowship as a head and neck surgical oncologist and a postdoctoral fellowship with a focus on the neurobiology of cancer.
Dr. Amit has an active research laboratory focusing on cancer-related neurogenesis and axonogenesis and on the role of neuro-immunology in cancer. One exciting finding of Dr. Amit’s lab involved describing a mechanism by which head and neck tumors can reprogram adrenergic signaling in neurons and the effect of targeting the peripheral nervous system on cancer initiation and progression. This will serve as a basisfor combining treatments targeting the nervous system with other therapies, such as immunotherapy, in the treatment of head and neck cancers. Dr. Amit is continuing his work by building a team to study how the neural microenvironment affects responses to chemotherapy and immunotherapy in patients with non-melanoma skin cancer and other cancers, and to develop novel strategies to combat resistance to these therapies.
Dr. Scheff is Assistant Professor and Principal Investigator in the Center for Neuroscience at the Hillman Cancer Center Research Pavillion at the University of Pittsburgh Medical Center. Her research is focused on the neurobiology of head and neck cancer and orofacial pain.
Bibliographic Information
Book Title: Cancer Neuroscience
Editors: Moran Amit, Nicole N. Scheff
DOI: https://doi.org/10.1007/978-3-031-32429-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Hardcover ISBN: 978-3-031-32428-4Published: 26 July 2023
Softcover ISBN: 978-3-031-33840-3Due: 10 October 2023
eBook ISBN: 978-3-031-32429-1Published: 25 July 2023
Edition Number: 1
Number of Pages: XII, 202
Number of Illustrations: 1 b/w illustrations, 20 illustrations in colour
Topics: Cancer Research, Neurosciences, Immunology, Cancer Research, Immunology